NDLI: Overexpression of LINC00160 predicts poor outcome and promotes progression of clear cell renal cell carcinoma.

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Overexpression of LINC00160 predicts poor outcome and promotes progression of clear cell renal cell carcinoma.

Content Provider	Europe PMC
Author	Cheng, Gong Yu, Yi Wang, Longwang Pan, Qiufeng
Abstract	Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal carcinoma and exhibits a high risk of invasion and metastasis. It is urgent to uncover a novel biomarker and clarify the underlying mechanism for ccRCC progression and metastasis. Although accumulating research has demonstrated that long non-coding RNAs (lncRNAs) play crucial roles in tumor progression, numerous lncRNAs in ccRCC are largely unknown. Therefore, we screened the differentially expressed lncRNAs among several GEO datasets and chose LNC00160 for further investigation. LNC00160 was significantly upregulated in ccRCC and high expression predicted poor prognosis; higher expression of LNC00160 was associated with advanced clinic pathological parameters in TCGA_KIRC Cohort. Knockdown of LNC00160 suppressed malignancy of ccRCC in vitro and in vivo. Correlation analysis and gene set enrichment analysis (GSEA) revealed that LNC00160 might be associated with Wnt signaling pathway, mTOR signaling pathway, fatty acid metabolism and cell cycle. In conclusion, our results demonstrated that LNC00160 acted as an oncogenic gene and a specific prognostic indicator for patients with ccRCC, and that LNC00160 might be a targeted intervention for ccRCC patients in the future.
Journal	Aging
Volume Number	12
PubMed Central reference number	PMC7202521
Issue Number	8
PubMed reference number	32315986
e-ISSN	19454589
DOI	10.18632/aging.103091
Language	English
Publisher	Impact Journals
Publisher Date	2020-04-21
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright © 2020 Cheng et al.
Subject Keyword	LINC00160 renal cancer biomarker prognosis
Content Type	Text
Resource Type	Article
Subject	Aging Cell Biology

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