Di-(2-ethylhexyl) Phthalate (DEHP) and Uterine Histological Characteristics.

Content Provider	Europe PMC
Author	Cheon, Yong-Pil
Copyright Year	2020
Abstract	AbstractPhthalates have a long industrial history. It is suspected that phthalates andtheir metabolites have detrimental effects on reproduction and development. Theyare well-known for their anti-androgenic effects. Several studies have indicatedthat phthalates and their metabolites are reprotoxic in males and endocrinedisruptors. Reproduction and embryogenesis occur in the uterus of femaleeutherian mammals. A horizontal analytical method is preferred to elucidate thetoxic effects of phthalates on human reproduction. Nevertheless, there are vastnumbers of known phthalates and not all of their modes of action have beenclarified. Di-(2-ethylhexyl) phthalate (DEHP) is a commonly used plasticizer andhas been the subject of numerous toxicological studies. However, few of thesehave reported on the toxic effects of DEHP, its metabolites, other phthalates,or mixtures on female reproduction. Acute and high doses of DEHP adverselyaffect uterine histology. Recently, it was disclosed that chronic exposures tolow doses of DEHP have endocrine disruption efficacy. DEHP induces variouscellular responses including modulation of the expression and regulation ofsteroid hormone receptors and transcription and paracrine factors. Uteri do notrespond uniformly to DEHP exposure. The phenotypic manifestations and effects onfertility in response to DEHP and its metabolites may vary with species,developmental stage, and generation. Hence, DEHP exposure may histological alterthe uterus and induce endometriosis, endometriosis, hyperplasia, myoma, anddevelopmental and reproductive toxicity.
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ISSN	24659525
Journal	Development & Reproduction [Dev Reprod]
Volume Number	24
PubMed Central reference number	PMC7201063
Issue Number	1
PubMed reference number	32411914
e-ISSN	24659541
DOI	10.12717/dr.2020.24.1.1
Language	English
Publisher	Korean Society of Developmental Biology
Publisher Date	2020-03-31
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of theCreative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permitsunrestricted non-commercial use, distribution, and reproduction in anymedium, provided the original work is properly cited. © Copyright 2019 The Korean Society of DevelopmentalBiology
Subject Keyword	Uterus Histology Phthalate Di-(2-ethylhexyl) phthalate (DEHP)
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology