NDLI: Hemosiderin deposition in lymph nodes of patients with plasma cell-type Castleman disease.

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Hemosiderin deposition in lymph nodes of patients with plasma cell-type Castleman disease.

Content Provider	Europe PMC
Author	Han, Yanyan Igawa, Takuro Ogino, Kyohei Nishikori, Asami Gion, Yuka Yoshino, Tadashi Sato, Yasuharu
Copyright Year	2020
Abstract	Plasma cell-type Castleman disease (PCD) is a rare idiopathic atypical lymphoproliferative disorder. It is difficult to differentiate between PCD and IgG4-related disease (IgG4-RD) based on histology alone. As PCD often presents with abundant hemosiderin deposition, lymph node lesions obtained from 22 PCD patients and 12 IgG4-RD patients were analyzed using Prussian blue staining to clarify whether hemosiderin deposition is effective in distinguishing between these two diseases. The analysis disclosed that hemosiderin was more densely deposited in PCD than in IgG4-RD. The median number of Prussian blue-positive cells ± standard deviation (SD) in PCD and IgG4-RD cases was 13 ± 36 cells/3HPFs and 4 ± 8 cells/3HPFs (P = 0.034), respectively. In addition, we analyzed the relationship between hemosiderin deposition and levels of serum interleukin (IL)-6, serum C-reactive protein (CRP), and anemia-related biomarkers. We found that hemosiderin deposition was significantly correlated with the level of serum CRP (P = 0.045); however, no significant correlation was observed between hemosiderin deposition and serum IL-6 levels (P = 0.204). A non-significant positive correlation was observed between hemosiderin deposition and serum hemoglobin levels (P=0.09). Furthermore, no significant correlation was observed between hemosiderin deposition and serum iron levels (P = 0.799). In conclusion, hemosiderin deposition characteristically observed in PCD may be related to the inflammatory aggressiveness of the disease and could be used for its differential diagnosis.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7187676&blobtype=pdf
ISSN	13464280
Journal	Journal of Clinical and Experimental Hematopathology : JCEH [J Clin Exp Hematop]
Volume Number	60
DOI	10.3960/jslrt.19037
PubMed Central reference number	PMC7187676
Issue Number	1
PubMed reference number	32037354
e-ISSN	18809952
Language	English
Publisher	JSLRT
Publisher Date	2020-03-08
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of theCreative Commons Attribution ShareAlike (CC BY-NC-SA) 4.0 License. © 2020 by The Japanese Society for Lymphoreticular Tissue Research
Subject Keyword	hemosiderin deposition plasma cell-type Castleman disease IgG4-related disease serum IL-6 serum C-reactive protein
Content Type	Text
Resource Type	Article
Subject	Medicine Hematology

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