Inflammatory pattern recognition receptors and their ligands: factors contributing to the pathogenesis of preeclampsia.

Content Provider	Europe PMC
Author	Sado, Toshiyuki Naruse, Katsuhiko Noguchi, Taketoshi Haruta, Shoji Yoshida, Shozo Tanase, Yasuhito Kitanaka, Takashi Oi, Hidekazu Kobayashi, Hiroshi
Abstract	ProblemPreeclampsia, a pregnancy-specific hypertensive syndrome, is one of the leading causes of premature births as well as fetal and maternal death. Preeclampsia lacks effective therapies because of the poor understanding of disease pathogenesis. The aim of this paper is to review molecular signaling pathways that could be responsible for the pathogenesis of preeclampsia.Method of studyThis article reviews the English-language literature for pathogenesis and pathophysiological mechanisms of preeclampsia based on genome-wide gene expression profiling and proteomic studies.ResultsWe show that the expression of the genes and proteins involved in response to stress, host-pathogen interactions, immune system, inflammation, lipid metabolism, carbohydrate metabolism, growth and tissue remodeling was increased in preeclampsia. Several significant common pathways observed in preeclampsia overlap the datasets identified in TLR (Toll-like receptor)- and RAGE (receptor for advanced glycation end products)-dependent signaling pathways. Placental oxidative stress and subsequent chronic inflammation are considered to be major contributors to the development of preeclampsia.ConclusionThis review summarizes recent advances in TLR- and RAGE-mediated signaling and the target molecules, and provides new insights into the pathogenesis of preeclampsia.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7095834&blobtype=pdf
ISSN	10233830
Journal	Inflammation Research [Inflamm Res]
Volume Number	60
DOI	10.1007/s00011-011-0319-4
PubMed Central reference number	PMC7095834
Issue Number	6
PubMed reference number	21380737
e-ISSN	1420908X
Language	English
Publisher	SP Birkhäuser Verlag Basel
Publisher Date	2011-03-06
Publisher Place	Basel
Access Restriction	Open
Rights License	This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. © Springer Basel AG 2011
Subject Keyword	Inflammation Oxidative stress Preeclampsia RAGE TLR
Content Type	Text
Resource Type	Article
Subject	Pharmacology Immunology