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Potential for the replication of the betanodavirus redspotted grouper nervous necrosis virus in human cell lines.
| Content Provider | Europe PMC |
|---|---|
| Author | Adachi, K. Ichinose, T. Watanabe, K. Kitazato, K. Kobayashi, N. |
| Abstract | SummaryThe determination of the host ranges of viruses is important because of the possible emergence of infectious agents, which may result from the zoonotic transmission of animal viruses to humans. The family Nodaviridae, whose members are non-enveloped, positive-stranded bipartite RNA viruses, is comprised of the genera Alphanodavirus and Betanodavirus, whose members predominantly infect insects and fish, respectively. The alphanodaviruses can also infect suckling mice and suckling hamsters, resulting in paralysis and death. Pigs near the site of isolation of the Nodamura virus (NoV), an alphanodavirus, have been reported to have high levels of NoV neutralizing antibody, suggesting that they may be part of the natural host range of this virus. Betanodaviruses are the causative agents of viral nervous necrosis, which occurs in several species of fish. However, little is known regarding the mechanism of infection of these viruses. Whether betanodaviruses can infect hosts other than fish remains unclear. In this study, we examined the possibility that a betanodavirus, redspotted grouper nervous necrosis virus (RGNNV), can infect human cell lines and showed that this virus can attach to the cells but cannot penetrate them, although human cells can support the replication of the betanodavirus when viral RNAs are transfected. The betanodavirus in its present form cannot infect human cells. |
| ISSN | 03048608 |
| Journal | Archives of Virology |
| Volume Number | 153 |
| PubMed Central reference number | PMC7086817 |
| Issue Number | 1 |
| PubMed reference number | 17906832 |
| e-ISSN | 14328798 |
| DOI | 10.1007/s00705-007-1051-9 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2007-09-28 |
| Publisher Place | Vienna |
| Access Restriction | Open |
| Rights License | This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. © Springer-Verlag 2007 |
| Subject Keyword | Coat Protein Human Cell Line Nervous Necrosis Virus Redspotted Grouper Nervous Necrosis Virus Flock House Virus |
| Content Type | Text |
| Resource Type | Article |
| Subject | Virology Medicine |
