NDLI: Glucuronidation as a metabolic barrier against zearalenone in rat everted intestine.

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Glucuronidation as a metabolic barrier against zearalenone in rat everted intestine.

Content Provider	Europe PMC
Author	IEKO, Takahiro INOUE, Sumire INOMATA, Yume INOUE, Hiroki FUJIKI, Jumpei IWANO, Hidetomo
Copyright Year	2020
Abstract	Zearalenone (ZON), produced by Fusarium fungi, exhibits estrogenic activity. Livestockcan be exposed to ZON orally through contaminating feeds such as cereals, leading toreproductive disorders such as infertility and miscarriage via endocrine systemdisruption. However, the details of ZON metabolism remain unclear, and the mechanism ofits toxicity has not been fully elucidated. In this study, we investigated the kinetics ofZON absorption and metabolism in rat segmented everted intestines. ZON absorption wasconfirmed in each intestine segment 60 min after application to the mucosal buffer at 10µM. Approximately half of the absorbed ZON was metabolized toα-zearalenol, which tended to be mainly glucuronidated in intestinal cells. In theproximal intestine, most of the glucuronide metabolized by intestinal cells was excretedto the mucosal side, suggesting that the intestine plays an important role as a first drugmetabolism barrier for ZON. However, in the distal intestine, ZON metabolites tended to betransported to the serosal side. Glucuronide transported to the serosal side could becarried via the systemic circulation to the local tissues, where it could be reactivatedby deconjugation. These results are important with regard to the mechanism of endocrinedisruption caused by ZON.
ISSN	09167250
Volume Number	82
PubMed Central reference number	PMC7041979
Issue Number	2
PubMed reference number	31839622
Journal	The Journal of Veterinary Medical Science [J. Vet. Med. Sci]
e-ISSN	13477439
DOI	10.1292/jvms.19-0570
Language	English
Publisher	The Japanese Society of Veterinary Science
Publisher Date	2019-12-16
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the CreativeCommons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0:https://creativecommons.org/licenses/by-nc-nd/4.0/) ©2020 The Japanese Society of Veterinary Science
Subject Keyword	absorption everted intestine glucuronidation metabolism zearalenone
Content Type	Text
Resource Type	Article
Subject	Veterinary

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