Analysis of pathogenetic process of fungal rhinosinusitis: Report of two cases.

Content Provider	Europe PMC
Author	Wang, Lin-Lin Chen, Feng-Ji Yang, Long-Su Li, Jie-En
Copyright Year	2020
Abstract	BACKGROUNDFungal rhinosinusitis is an infectious and/or allergic disease caused by fungi in the sinus and nasal cavity. Due to the warm and humid climate in Guangxi Zhuang Autonomous Region, the incidence of fungal rhinosinusitis is higher than that in other provinces. However, its physiological mechanism is not yet clear. Not every patient colonized by fungi develops a fungal infection. To a large extent, the immune status of the patient determines the nature of fungal disease in the nasal passages. The pathologic process of progression from harmless fungal colonization to fungal rhinosinusitis is unclear and has not been reported.CASE SUMMURYWe report two patients, one who developed fungal rhinosinusitis 1.5 years after surgery performed to treat an inverted papilloma, and the other with a history of hypertension and cerebral infarction. Both patients recovered from their surgeries. An average time of 2.5 years elapsed from the development of maxillary sinus cysts to the development of fungal rhinosinusitis.CONCLUSIONAccording to these case reports, we speculate that the progression of fungal rhinosinusitis from harmless colonization to disease onset requires approximately one to three years and that the length of the process may be related to underlying diseases, surgical treatment, deficient autoimmune status, and abuse of hormone antibiotics and hormones. Additional data are needed to conduct relevant studies to appropriately prevent and treat fungal rhinosinusitis.
Volume Number	8
PubMed Central reference number	PMC7000939
Issue Number	2
PubMed reference number	32047798
Journal	World Journal of Clinical Cases
e-ISSN	23078960
DOI	10.12998/wjcc.v8.i2.451
Language	English
Publisher	Baishideng Publishing Group Inc
Publisher Date	2020-01-01
Access Restriction	Open
Rights License	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Subject Keyword	Fungal rhinosinusitis Aspergillosis Fungus ball Sinus surgery Classification Diagnosis Case report
Content Type	Text
Resource Type	Article
Subject	Medicine