NDLI: Curcumin's Effect on COX-2 and IL-10 Serum in Preeclampsia's Patient Undergo Sectio Caesarea with Spinal Anesthesia.

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Curcumin's Effect on COX-2 and IL-10 Serum in Preeclampsia's Patient Undergo Sectio Caesarea with Spinal Anesthesia.

Content Provider	Europe PMC
Author	Fadinie, Wulan Lelo, Aznan Wijaya, Dadik Wahyu Lumbanraja, Sarma Nursani
Copyright Year	2019
Abstract	BACKGROUND:Curcumin is a major component in curcuminoid which acts as an anti-inflammatory agent. Curcumin affects several biological markers that are thought to play a role in the pathogenesis of preeclampsia such as IL-10 and COX-2, resulting in an improvement in pregnant women with preeclampsia.AIM:To see the effect of perioperative curcumin administration on IL-10 and COX-2 in preeclamptic patients undergoing caesarean section under spinal anaesthesia.METHODS:This study was a double-blind, randomised clinical trial conducted at Pirngadi Hospital, USU Hospital and Sundari General Hospital Medan as a hospital network of Faculty of Medicine, North Sumatra University. Group 1 received a drug containing curcumin (as a treatment), and another group received a placebo (as a control).RESULTS:There were no significant differences in the median values of COX-2 and IL-10 before and after treatment and also the p-values were greater than 0.05 in both groups (control and treatment).CONCLUSION:There is no significant difference between the use of curcumin on serum COX-2 and IL-10 levels.
Journal	Open Access Macedonian Journal of Medical Sciences
Volume Number	7
PubMed Central reference number	PMC6980822
Issue Number	20
PubMed reference number	32002054
e-ISSN	18579655
DOI	10.3889/oamjms.2019.426
Language	English
Publisher	Republic of Macedonia
Publisher Date	2019-10-14
Publisher Place	ID Design 2012/DOOEL Skopje
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0) Copyright: © 2019 Wulan Fadinie, Aznan Lelo, Dadik Wahyu Wijaya, Sarma Nursani Lumbanraja.
Subject Keyword	Curcumin Cyclooxygenase 2 (COX-2) Interleukin-10 (IL-10) Preeclampsia Spinal Anesthesia
Content Type	Text
Resource Type	Article
Subject	Medicine

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