Dietary lipids, gut microbiota and lipid metabolism.

Content Provider	Europe PMC
Author	Schoeler, Marc Caesar, Robert
Abstract	The gut microbiota is a central regulator of host metabolism. The composition and function of the gut microbiota is dynamic and affected by diet properties such as the amount and composition of lipids. Hence, dietary lipids may influence host physiology through interaction with the gut microbiota. Lipids affect the gut microbiota both as substrates for bacterial metabolic processes, and by inhibiting bacterial growth by toxic influence. The gut microbiota has been shown to affect lipid metabolism and lipid levels in blood and tissues, both in mice and humans. Furthermore, diseases linked to dyslipidemia, such as non-alcoholic liver disease and atherosclerosis, are associated with changes in gut microbiota profile. The influence of the gut microbiota on host lipid metabolism may be mediated through metabolites produced by the gut microbiota such as short-chain fatty acids, secondary bile acids and trimethylamine and by pro-inflammatory bacterially derived factors such as lipopolysaccharide. Here we will review the association between gut microbiota, dietary lipids and lipid metabolism
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6938793&blobtype=pdf
ISSN	13899155
Journal	Reviews in Endocrine & Metabolic Disorders [Rev Endocr Metab Disord]
Volume Number	20
DOI	10.1007/s11154-019-09512-0
PubMed Central reference number	PMC6938793
Issue Number	4
PubMed reference number	31707624
e-ISSN	15732606
Language	English
Publisher	Springer US
Publisher Date	2019-12-01
Publisher Place	New York
Access Restriction	Open
Rights License	Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. © The Author(s) 2019
Subject Keyword	Diet Dietary lipid Lipid Fatty acid Gut microbiota Microbiome Dysbiosis Dyslipidemia Lipid metabolism NAFLD Non-alcoholic liver disease TMA TMAO Trimethylamine N-oxide Inflammation Lipopolysaccharides LPS Gut permeability FXR TGR5 Bile acid Atherosclerosis
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Endocrinology