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The recovery of standing and locomotion after spinal cord injury does not require task-specific training.
| Content Provider | Europe PMC |
|---|---|
| Author | Harnie, Jonathan Doelman, Adam de Vette, Emmanuelle Audet, Johannie Desrochers, Etienne Gaudreault, Nathaly Frigon, Alain |
| Editor | Calabrese, Ronald L Ramirez, Jan-Marino |
| Copyright Year | 2019 |
| Abstract | After complete spinal cord injury, mammals, including mice, rats and cats, recover hindlimb locomotion with treadmill training. The premise is that sensory cues consistent with locomotion reorganize spinal sensorimotor circuits. Here, we show that hindlimb standing and locomotion recover after spinal transection in cats without task-specific training. Spinal-transected cats recovered full weight bearing standing and locomotion after five weeks of rhythmic manual stimulation of triceps surae muscles (non-specific training) and without any intervention. Moreover, cats modulated locomotor speed and performed split-belt locomotion six weeks after spinal transection, functions that were not trained or tested in the weeks prior. This indicates that spinal networks controlling standing and locomotion and their interactions with sensory feedback from the limbs remain largely intact after complete spinal cord injury. We conclude that standing and locomotor recovery is due to the return of neuronal excitability within spinal sensorimotor circuits that do not require task-specific activity-dependent plasticity. |
| Journal | eLife |
| Volume Number | 8 |
| PubMed Central reference number | PMC6924957 |
| PubMed reference number | 31825306 |
| e-ISSN | 2050084X |
| DOI | 10.7554/elife.50134 |
| Language | English |
| Publisher | eLife Sciences Publications, Ltd |
| Publisher Date | 2019-12-11 |
| Access Restriction | Open |
| Rights License | This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. © 2019, Harnie et al |
| Subject Keyword | spinal cord injury locomotor training functional recovery task-specificity central pattern generator Felis catus Cat |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Microbiology Neuroscience Medicine Biochemistry, Genetics and Molecular Biology |
