NDLI: Effects of trans-10,cis-12 conjugated linoleic acid on body composition in genetically obese mice.

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Effects of trans-10,cis-12 conjugated linoleic acid on body composition in genetically obese mice.

Content Provider	Europe PMC
Author	Hur, Sunjin Whitcomb, Faith Rhee, Siyeon Park, Yooheon Good, Deborah J. Park, Yeonhwa
Copyright Year	2009
Abstract	Conjugated linoleic acid (CLA) has shown a number of biologically beneficial effects, including prevention of obesity. The purpose of this study was to test effects of dietary supplementation of 0.5% trans-10,cis-12 CLA in a high fat diet in neuronal basic helix-loop-helix 2 knock-out animals (N2KO), which is a unique animal model representing adult-on-set inactivity-related obesity. Eight wild-type (WT) and eight N2KO female mice were fed either 0.5% trans-10,cis-12 CLA-containing diet or control diet (with 20% soybean oil diet) for 12 weeks. Body weights, food intake, adipose tissue weights, body compositions, and blood parameters were analyzed. Overall, N2KO animals had greater body weights, food intake, adi-pose tissue weights, and body fat compared to WT animals. CLA supplementation decreased overall body weights and total fat, and the effect of dietary CLA on adipose tissue reduction was greater in N2KO than in WT mice. Serum leptin and triglyc-eride levels were reduced by CLA in both N2KO and WT animals compared to control animals, while there was no effect by CLA on serum cholesterol. The effect of CLA to lower fat mass, increase lean body mass, and lower serum leptin and triglyc-erides in sedentary mice supports the possibility of using CLA to prevent or alleviate ailments associated with obesity.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6918522&blobtype=pdf
Page Count	8
ISSN	1096620X
Volume Number	12
DOI	10.1089/jmf.2008.0110
PubMed Central reference number	PMC6918522
Issue Number	1
PubMed reference number	19298196
Journal	Journal of Medicinal Food [J Med Food]
e-ISSN	15577600
Language	English
Publisher	Mary Ann Liebert, Inc., publishers
Publisher Date	2009-02-01
Publisher Place	USA
Access Restriction	Open
Rights License	Copyright 2009, Mary Ann Liebert, Inc., publishers, and Korean Society of Food Science and Nutrition
Subject Keyword	adipose tissue CLA (conjugated linoleic acid) leptin Nhlh2 knockout mice
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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