NDLI: Inositol 1,4,5-trisphosphate receptor in the liver: Expression and function.

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Inositol 1,4,5-trisphosphate receptor in the liver: Expression and function.

Content Provider	Europe PMC
Author	Lemos, Fernanda de Oliveira Florentino, Rodrigo M Lima Filho, Antônio Carlos Melo dos Santos, Marcone Loiola Leite, M Fatima
Copyright Year	2019
Abstract	The liver is a complex organ that performs several functions to maintain homeostasis. These functions are modulated by calcium, a second messenger that regulates several intracellular events. In hepatocytes and cholangiocytes, which are the epithelial cell types in the liver, inositol 1,4,5-trisphosphate (InsP3) receptors (ITPR) are the only intracellular calcium release channels. Three isoforms of the ITPR have been described, named type 1, type 2 and type 3. These ITPR isoforms are differentially expressed in liver cells where they regulate distinct physiological functions. Changes in the expression level of these receptors correlate with several liver diseases and hepatic dysfunctions. In this review, we highlight how the expression level, modulation, and localization of ITPR isoforms in hepatocytes and cholangiocytes play a role in hepatic homeostasis and liver pathology.
ISSN	10079327
Volume Number	25
PubMed Central reference number	PMC6886013
Issue Number	44
PubMed reference number	31802829
Journal	World Journal of Gastroenterology [World J. Gastroenterol]
e-ISSN	22192840
DOI	10.3748/wjg.v25.i44.6483
Language	English
Publisher	Baishideng Publishing Group Inc
Publisher Date	2019-11-01
Access Restriction	Open
Rights License	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Subject Keyword	Inositol 1,4,5-trisphosphate receptor Liver Calcium signaling Hepatocytes and cholangiocytes
Content Type	Text
Resource Type	Article
Subject	Gastroenterology

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