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Construction of a high-density genetic linkage map and mapping of quantitative trait loci for growth-related traits in silver carp (Hypophthalmichthys molitrix).
| Content Provider | Europe PMC |
|---|---|
| Author | Wang, Xinhua Liu, Haiyang Pang, Meixia Fu, Beide Yu, Xiaomu He, Shunping Tong, Jingou |
| Abstract | High-density genetic map and quantitative trait loci (QTL) mapping are powerful tools for identifying genomic regions that may be responsible for such polygenic trait as growth. A high-density genetic linkage map was constructed by sequencing 198 individuals in a F1 family of silver carp (Hypophthalmichthys molitrix) in this study. This genetic map spans a length of 2,721.07 cM with 3,134 SNPs distributed on 24 linkage groups (LGs). Comparative genomic mapping presented a high level of syntenic relationship between silver carp and zebrafish. We detected one major and nineteen suggestive QTL for 4 growth-related traits (body length, body height, head length and body weight) at 6, 12 and 18 months post hatch (mph), explaining 10.2~19.5% of phenotypic variation. All six QTL for growth traits of 12 mph generally overlapped with QTL for 6 mph, while the majority of QTL for 18 mph were identified on two additional LGs, which may reveal a different genetic modulation during early and late muscle growth stages. Four potential candidate genes were identified from the QTL regions by homology searching of marker sequences against zebrafish genome. Hepcidin, a potential candidate gene identified from a QTL interval on LG16, was significantly associated with growth traits in the analyses of both phenotype-SNP association and mRNA expression between small-size and large-size groups of silver carp. These results provide a basis for elucidating the genetic mechanisms for growth and body formation in silver carp, a world aquaculture fish. |
| Journal | Scientific Reports [Sci Rep] |
| Volume Number | 9 |
| DOI | 10.1038/s41598-019-53469-8 |
| PubMed Central reference number | PMC6877629 |
| Issue Number | 1 |
| PubMed reference number | 31767872 |
| e-ISSN | 20452322 |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2019-11-25 |
| Publisher Place | London |
| Access Restriction | Open |
| Subject Keyword | Reverse transcription polymerase chain reaction Comparative genomics Genetic markers |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
