Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking.

Content Provider	Europe PMC
Author	Sikdar, Sinjini Joehanes, Roby Joubert, Bonnie R Xu, Cheng-Jian Vives-Usano, Marta Rezwan, Faisal I Felix, Janine F Ward, James M Guan, Weihua Richmond, Rebecca C Brody, Jennifer A Küpers, Leanne K Baïz, Nour Håberg, Siri E Smith, Jennifer A Reese, Sarah E Aslibekyan, Stella Hoyo, Cathrine Dhingra, Radhika Markunas, Christina A Xu, Tao Reynolds, Lindsay M Just, Allan C Mandaviya, Pooja R Ghantous, Akram Bennett, Brian D Wang, Tianyuan Consortium, The BIOS Bakulski, Kelly M Melen, Erik Zhao, Shanshan Jin, Jianping Herceg, Zdenko van Meurs, Joyce Taylor, Jack A Baccarelli, Andrea A Murphy, Susan K Liu, Yongmei Munthe-Kaas, Monica Cheng Deary, Ian J Nystad, Wenche Waldenberger, Melanie Annesi-Maesano, Isabella Conneely, Karen Jaddoe, Vincent WV Arnett, Donna Snieder, Harold Kardia, Sharon LR Relton, Caroline L Ong, Ken K Ewart, Susan Moreno-Macias, Hortensia Romieu, Isabelle Sotoodehnia, Nona Fornage, Myriam Motsinger-Reif, Alison Koppelman, Gerard H Bustamante, Mariona Levy, Daniel London, Stephanie J
Copyright Year	2019
Abstract	Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6836223&blobtype=pdf
Page Count	14
ISSN	17501911
Volume Number	11
DOI	10.2217/epi-2019-0066
PubMed Central reference number	PMC6836223
Issue Number	13
PubMed reference number	31536415
Journal	Epigenomics
e-ISSN	1750192X
Language	English
Publisher	Future Medicine Ltd
Publisher Date	2019-09-19
Publisher Place	London, UK
Access Restriction	Open
Rights License	This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License © 2019 Sinjini Sikdar
Subject Keyword	cigarette smoking epigenetics infant maternal exposure methylation
Content Type	Text
Resource Type	Article
Subject	Genetics Cancer Research