Micronized Purified Flavonoid Fraction (MPFF) for Patients Suffering from Chronic Venous Disease: A Review of New Evidence.

Content Provider	Europe PMC
Author	Ulloa, Jorge H.
Abstract	Chronic venous disease (CVD) is both prevalent and unavoidable in many people as a result of persistent or unalterable risk factors, the most important of which are advanced age, excess body weight, and family history. Given this inevitability, medical treatment is required to alleviate symptoms and slow disease progression. Venoactive drug therapy is emerging as a valuable treatment option for many CVD patients and micronized purified flavonoid fraction (MPFF) is the most widely prescribed and well-studied venoactive drug available. Recent evidence from animal models of venous hypertension and from clinical trials, as well as from systematic reviews, shows that MPFF is effective at alleviating many of the most common symptoms of CVD including leg pain, leg heaviness, sensations of swelling, cramps, and functional discomfort. In addition, MPFF improves the clinical signs of redness, skin changes, and edema, and improves quality of life. Collectively, these findings support the strong recommendation for MPFF treatment found in the 2018 international guidelines for the management of CVD.Funding: Servier.Supplementary InformationThe online version contains supplementary material available at 10.1007/s12325-019-0884-4.
ISSN	0741238X
Journal	Advances in Therapy
Volume Number	36
PubMed Central reference number	PMC6824339
Issue Number	suppl 1
PubMed reference number	30758743
e-ISSN	18658652
DOI	10.1007/s12325-019-0884-4
Language	English
Publisher	Springer Healthcare
Publisher Date	2019-02-13
Publisher Place	Cheshire
Access Restriction	Open
Rights License	Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. © The Author(s) 2019
Subject Keyword	Cardiology Chronic venous disease Chronic venous insufficiency Flavonoid Inflammation Micronized purified flavonoid fraction MPFF Venoactive drugs Venous hypertension
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical)