NDLI: Sonic Hedgehog signaling pathway as a potential target to inhibit the progression of hepatocellular carcinoma.

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Sonic Hedgehog signaling pathway as a potential target to inhibit the progression of hepatocellular carcinoma.

Content Provider	Europe PMC
Author	Jeng, Kuo-Shyang Jeng, Chi-Juei Jeng, Wen-Juei Sheen, I-Shyan Li, Shih-Yun Leu, Chuen-Miin Tsay, Yeou-Guang Chang, Chiung-Fang
Copyright Year	2019
Abstract	Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-associated mortality worldwide. Hepatocarcinogenesis involves numerous interlinked factors and processes, including the Sonic hedgehog (Shh) signaling pathway, which participates in the carcinogenesis, progression, invasiveness, recurrence and cancer stem cell maintenance of HCC. The Shh signaling pathway is activated by ligands that bind to their receptor protein, Protein patched homolog (Ptch). The process of Shh ligand binding to Ptch weakens the inhibition of smoothened homolog (SMO) and activates signal transduction via glioma-associated oncogene homolog (Gli) transcription factors. The overexpression of Shh pathway molecules, including Shh, Ptch-1, Gli and SMO has been indicated in patients with HCC. It has also been suggested that the Shh signaling pathway exhibits cross-talk between numerous other signaling pathways. The inactivation of the Shh signaling pathway reduces HCC growth, increases radio-sensitivity and increases the beneficial effect of chemotherapy in HCC treatment. Therefore, inhibition of the Shh pathway may be an effective target therapy that can be used in the treatment of HCC.
ISSN	17921074
Journal	Oncology Letters
Volume Number	18
PubMed Central reference number	PMC6781692
Issue Number	5
PubMed reference number	31611946
e-ISSN	17921082
DOI	10.3892/ol.2019.10826
Language	English
Publisher	D.A. Spandidos
Publisher Date	2019-09-09
Access Restriction	Open
Rights License	This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Copyright: © Jeng et al.
Subject Keyword	sonic hedgehog signaling pathway hepatocellular carcinoma recurrence cancer stem cells
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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