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Identification of a 3-mRNA signature as a novel potential prognostic biomarker in patients with ovarian serous cystadenocarcinoma in G2 and G3.
| Content Provider | Europe PMC |
|---|---|
| Author | Zhou, Jiahua Yi, Yeye Wang, Congjun Su, Cheng Luo, Yige |
| Copyright Year | 2019 |
| Abstract | The use of mRNAs as biomarkers serves to diagnose, treat, as well as aid the prognosis of cancer. The present study involved an analysis of mRNAs in the cell cycle at the G2 and G3 tumor grades for the prognosis of ovarian serous cystadenocarcinoma (OSC) using 364 clinical samples (G2:G3=42:322). Statistics aided the identification of NPFFR2, XPNPEP2 and CELA3B; the 3-mRNA model that allows for classification of patients into high- and low-risk groups using a median value of 0.9580745. The rates of survival varied (P=0.00149) and the independent detection of stratification of the risk of this disease was validated with success using the 3-mRNA signature, which was demonstrated to be more successful than the weight model. This approach was revealed to provide the prognosis of grade G2 and G3 in patients with OSC compared with factors used traditionally. Compared with traditional factors, this 3-mRNA model was demonstrated to be the only and independent prognostic factor for patients with G2 and G3 stage OSC. A literature survey was also performed in the present study in order to assess the role of the 3 genes and indirectly prove their effectiveness. The establishment of this new genetic model will enhance prospective prognosis and treatment for patients with OSC. |
| ISSN | 17921074 |
| Journal | Oncology Letters |
| Volume Number | 18 |
| PubMed Central reference number | PMC6757305 |
| Issue Number | 4 |
| PubMed reference number | 31579405 |
| e-ISSN | 17921082 |
| DOI | 10.3892/ol.2019.10701 |
| Language | English |
| Publisher | D.A. Spandidos |
| Publisher Date | 2019-08-01 |
| Access Restriction | Open |
| Rights License | This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Copyright: © Zhou et al. |
| Subject Keyword | ovarian serous cystadenocarcinoma mRNA prognosis overall survival The Cancer Genome Atlas |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
