Early Left Ventricular Involvement Detected by Cardiovascular Magnetic Resonance Feature Tracking in Arrhythmogenic Right Ventricular Cardiomyopathy: The Effects of Left Ventricular Late Gadolinium Enhancement and Right Ventricular Dysfunction.

Content Provider	Europe PMC
Author	Chen, Xiuyu Li, Lu Cheng, Huaibin Song, Yanyan Ji, Keshan Chen, Lin Han, Tongtong Lu, Minjie Zhao, Shihua
Abstract	BackgroundLeft ventricular (LV) involvement is common in arrhythmogenic right ventricular cardiomyopathy (ARVC). We aim to evaluate LV involvement in ARVC patients by cardiovascular magnetic resonance feature tracking.Methods and ResultsSixty‐eight patients with ARVC and 30 controls were prospectively enrolled. ARVC patients were divided into 2 subgroups: the preserved LV ejection fraction (LVEF) group (LVEF ≥55%, n=27) and the reduced LVEF group (LVEF <55%, n=41). Cardiovascular magnetic resonance with late gadolinium enhancement (LGE) and cardiovascular magnetic resonance feature tracking were performed in all subjects. LV global and regional (basal, mid, apical) peak strain (PS) in radial, circumferential and longitudinal directions were assessed, respectively. Right ventricular global PS in three directions were also analyzed. Compared with the controls, LV global and regional PS were all significantly impaired in the reduced LVEF group (all P<0.05). However, only LV global longitudinal PS as well as mid and apical longitudinal PS were impaired in the preserved LVEF group (all P<0.05), and all these parameters were significantly associated with right ventricular global radial PS (r=−0.47, −0.47, and −0.49, respectively, all P<0.001). The reduced LVEF group showed significantly higher prevalence of LGE (95.10% versus 63.00%, P=0.002) than the preserved LVEF group. Moreover, LV radial PS was significantly reduced in LV segments with LGE (33.15±20.42%, n=46) than those without LGE (41.25±15.98%, n=386) in the preserved LVEF group (P=0.016).ConclusionsIn patients with ARVC, cardiovascular magnetic resonance feature tracking could detect early LV dysfunction, which was associated with LV myocardial LGE and right ventricular dysfunction.
Page Count	9
Journal	Journal of the American Heart Association
Volume Number	8
PubMed Central reference number	PMC6755833
Issue Number	17
PubMed reference number	31441357
e-ISSN	20479980
DOI	10.1161/jaha.119.012989
Language	English
Publisher	John Wiley and Sons Inc.
Publisher Date	2019-08-23
Publisher Place	Hoboken
Access Restriction	Open
Rights License	This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. © 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.
Subject Keyword	arrhythmogenic right ventricular dysplasia magnetic resonance imaging strain ventricle Magnetic Resonance Imaging (MRI) Cardiomyopathy
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine