NDLI: Circular RNAs: A novel target among non‑coding RNAs with potential roles in malignant tumors (Review).

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Circular RNAs: A novel target among non‑coding RNAs with potential roles in malignant tumors (Review).

Content Provider	Europe PMC
Author	Zhao, Weisong Dong, Man Pan, Jinru Wang, Yajie Zhou, Jingyi Ma, Jianjun Liu, Shaoyang
Copyright Year	2019
Abstract	Circular RNAs (circRNAs) are a class of non-coding RNAs that are generated via alternative back-splicing, which connects the terminal 5′ and 3′ends. Due to their unique loop structure, circRNAs are resistant to ribonucleases and more stable than linear RNAs. In vivo, they are usually highly conserved and stably expressed in tissue/developmental-stage-specific manners. Generally, circRNAs function as microRNA sponges and splicing regulators, as well as in protein binding and transcription. Some circRNAs contain open reading frames with internal ribosomal entry site elements and can thus encode specific proteins. Previously, circRNAs were thought to be erroneous splicing products or by-products of mRNA splicing. With the development of the next-generation sequencing techniques, it has become increasingly clear that circRNAs are abundantly widespread in eukaryotes and that they play significant roles in malignant tumor progression. The present review briefly introduces the biogenesis and functions of circRNAs, as well as summarizes recent research in several common malignancies. The present review also addresses the prospects of circRNAs in clinical applications.
ISSN	17912997
Journal	Molecular Medicine Reports
Volume Number	20
PubMed Central reference number	PMC6755165
Issue Number	4
PubMed reference number	31485661
e-ISSN	17913004
DOI	10.3892/mmr.2019.10637
Language	English
Publisher	D.A. Spandidos
Publisher Date	2019-09-02
Access Restriction	Open
Rights License	This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Copyright: © Zhao et al.
Subject Keyword	circular RNAs microRNA malignant tumor biomarker therapy
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Biology Biochemistry Cancer Research Molecular Medicine Oncology

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