NDLI: Serum retinol-binding protein 4 is associated with the presence and severity of coronary artery disease in patients with subclinical hypothyroidism.

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Serum retinol-binding protein 4 is associated with the presence and severity of coronary artery disease in patients with subclinical hypothyroidism.

Content Provider	Europe PMC
Author	Sun, Hui-Xian Ji, Hui-Hong Chen, Xiao-Lin Wang, Li Wang, Yue Shen, Xi-Yu Lu, Xiang Gao, Wei Wang, Lian-Sheng
Abstract	Subclinical hypothyroidism (SCH) plays a crucial role in the development and progression of coronary heart disease (CAD). Retinol-binding protein 4 (RBP4) is an adipokine correlated with cardiovascular diseases. Recent studies found that RBP4 levels are increased in patients with SCH. However, the relationship of RBP4 with CAD in SCH patients remains unclear. A total of 199 SCH patients (148 with CAD and 51 without CAD) and 102 healthy controls were enrolled in this study. Serum RBP4 was increased in SCH patients than controls. Moreover, serum RBP4 was higher in SCH patients with CAD. Although there was no significant difference of metabolic parameters between SCH patients with and without CAD, serum RBP4 was positively correlated with body mass index, total cholesterol, and low-density lipoprotein cholesterol, as well as thyroid stimulating hormone. Multivariable logistic regression analyses revealed elevated RBP4 was correlated with increased risk for CAD in SCH patients. Serum RBP4 levels were also increased as the number of stenosed vessels increased. Furthermore, increased RBP4 was positively correlated with the severity of CAD quantified by the Gensini score. Our findings demonstrate that serum RBP4 is associated with the presence and severity of CAD in patients with SCH.
Journal	Aging
Volume Number	11
PubMed Central reference number	PMC6660052
Issue Number	13
PubMed reference number	31278889
e-ISSN	19454589
DOI	10.18632/aging.102065
Language	English
Publisher	Impact Journals
Publisher Date	2019-07-01
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2019 Sun et al.
Subject Keyword	retinol-binding protein 4 coronary artery disease subclinical hypothyroidism
Content Type	Text
Resource Type	Article
Subject	Aging Cell Biology

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