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Adult stem cells at work: regenerating skeletal muscle.
| Content Provider | Europe PMC |
|---|---|
| Author | Schmidt, Manuel Schüler, Svenja C. Hüttner, Sören S. von Eyss, Björn von Maltzahn, Julia |
| Abstract | Skeletal muscle regeneration is a finely tuned process involving the activation of various cellular and molecular processes. Satellite cells, the stem cells of skeletal muscle, are indispensable for skeletal muscle regeneration. Their functionality is critically modulated by intrinsic signaling pathways as well as by interactions with the stem cell niche. Here, we discuss the properties of satellite cells, including heterogeneity regarding gene expression and/or their phenotypic traits and the contribution of satellite cells to skeletal muscle regeneration. We also summarize the process of regeneration with a specific emphasis on signaling pathways, cytoskeletal rearrangements, the importance of miRNAs, and the contribution of non-satellite cells such as immune cells, fibro-adipogenic progenitor cells, and PW1-positive/Pax7-negative interstitial cells. |
| ISSN | 1420682X |
| Journal | Cellular and Molecular Life Sciences |
| Volume Number | 76 |
| PubMed Central reference number | PMC6586695 |
| Issue Number | 13 |
| PubMed reference number | 30976839 |
| e-ISSN | 14209071 |
| DOI | 10.1007/s00018-019-03093-6 |
| Language | English |
| Publisher | Springer International Publishing |
| Publisher Date | 2019-04-11 |
| Publisher Place | Gewerbestrasse 11, Cham, Ch 6330, Switzerland |
| Access Restriction | Open |
| Rights License | Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. © The Author(s) 2019 |
| Subject Keyword | Satellite cell Stem cell Skeletal muscle Regeneration Myogenesis Heterogeneity |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience |
