NDLI: Self-organized reactivation maintains and reinforces memories despite synaptic turnover.

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Self-organized reactivation maintains and reinforces memories despite synaptic turnover.

Content Provider	Europe PMC
Author	Fauth, Michael Jan van Rossum, Mark CW
Editor	Skinner, Frances K Marder, Eve
Copyright Year	2019
Abstract	Long-term memories are believed to be stored in the synapses of cortical neuronal networks. However, recent experiments report continuous creation and removal of cortical synapses, which raises the question how memories can survive on such a variable substrate. Here, we study the formation and retention of associative memory in a computational model based on Hebbian cell assemblies in the presence of both synaptic and structural plasticity. During rest periods, such as may occur during sleep, the assemblies reactivate spontaneously, reinforcing memories against ongoing synapse removal and replacement. Brief daily reactivations during rest-periods suffice to not only maintain the assemblies, but even strengthen them, and improve pattern completion, consistent with offline memory gains observed experimentally. While the connectivity inside memory representations is strengthened during rest phases, connections in the rest of the network decay and vanish thus reconciling apparently conflicting hypotheses of the influence of sleep on cortical connectivity.
Journal	eLife
Volume Number	8
PubMed Central reference number	PMC6546393
PubMed reference number	31074745
e-ISSN	2050084X
DOI	10.7554/elife.43717
Language	English
Publisher	eLife Sciences Publications, Ltd
Publisher Date	2019-05-10
Access Restriction	Open
Rights License	This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. © 2019, Fauth and van Rossum
Subject Keyword	synaptic plasticity long-term memory synaptic turnover Hebbian cell assemblies computational model
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Neuroscience Medicine Biochemistry, Genetics and Molecular Biology

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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