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Non-motor Comorbidity of Myasthenia Gravis: Myasthenia Gravis as a Systemic Immunological Disorder Involving Non-motor Systems.
| Content Provider | Europe PMC |
|---|---|
| Author | Tajima, Yasutaka Yaguchi, Hiroaki Mito, Yasunori |
| Abstract | To explore non-motor comorbidities of myasthenia gravis (MG), we present two cases of thymoma-associated MG patients. Alopecia, pure red cell aplasia, and thymoma- associated multiorgan autoimmunity were observed in Case 1, and alopecia, thrombocytopenia, hypogammaglobulinemia and nephrotic syndrome were observed in Case 2. In both cases, autoreactive T lymphocytes inappropriately stimulated by thymus tissue may have played key roles in generating the various autoimmune-associated symptoms. Consequently, systemic immunological involvement due to the thymoma-associated breakdown of immunoregulations in both motor and non-motor systems should be considered in MG patients. |
| ISSN | 09182918 |
| Volume Number | 58 |
| PubMed Central reference number | PMC6543207 |
| Issue Number | 9 |
| PubMed reference number | 30568129 |
| Journal | Internal Medicine [Intern. Med] |
| e-ISSN | 13497235 |
| DOI | 10.2169/internalmedicine.1990-18 |
| Language | English |
| Publisher | The Japanese Society of Internal Medicine |
| Publisher Date | 2018-12-18 |
| Access Restriction | Open |
| Rights License | The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). Copyright © 2019 by The Japanese Society of Internal Medicine |
| Subject Keyword | myasthenia gravis thymoma pure red cell aplasia alopecia thymoma-associated multiorgan autoimmunity |
| Content Type | Text |
| Resource Type | Article |
| Subject | Internal Medicine |