NDLI: The PI3KCA and AKT Inhibitory Activities of <i>Litsea Cubeba</i> Lour. Fruits and Heartwoods Towards Hela Cells.

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The PI3KCA and AKT Inhibitory Activities of Litsea Cubeba Lour. Fruits and Heartwoods Towards Hela Cells.

Content Provider	Europe PMC
Author	Dalimunthe, Aminah Hasibuan, Poppy Anjelisa Zaitun Satria, Denny
Copyright Year	2019
Abstract	AIM:To investigated the activities of chloroform fractions at pH 7 of Litsea cubeba Lour. Fruits and heartwoods (CF-7F and CF-7H) in decrease expression of PI3KCA, Akt-1 and Akt-2 genes towards cervical cancer cell culture (HeLa) experiments in vitro.MATERIAL AND METHODS:CF-7F and CF-7H (12.5 and 25 µg/mL) were tested for its potential inhibition on gene expression of PI3KCA, Akt-1 and Akt-2 genes by Reverse Transcription-Polymerase Chain Reaction (RT-PCR) method.RESULT:CF-7F and CF-7H were showed the activity to reduce the expression of PI3KCA, Akt-1 and Akt-2 genes.CONCLUSION:Our results suggest that CF-7F and CF-7H significantly inhibit the expression of PI3KCA, Akt-1 and Akt-2 genes.
Journal	Open Access Macedonian Journal of Medical Sciences
Volume Number	7
PubMed Central reference number	PMC6542386
Issue Number	9
PubMed reference number	31198447
e-ISSN	18579655
DOI	10.3889/oamjms.2019.317
Language	English
Publisher	Republic of Macedonia
Publisher Date	2019-05-14
Publisher Place	ID Design 2012/DOOEL Skopje
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). Copyright: © 2019 Aminah Dalimunthe, Poppy Anjelisa Zaitun Hasibuan, Denny Satria.
Subject Keyword	Litsea cubeba Lour Fruits Heartwoods PI3KCA Akt
Content Type	Text
Resource Type	Article
Subject	Medicine

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