NDLI: Immunoglobulin‑like transcript 4 and human leukocyte antigen‑G interaction promotes the progression of human colorectal cancer.

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Immunoglobulin‑like transcript 4 and human leukocyte antigen‑G interaction promotes the progression of human colorectal cancer.

Content Provider	Europe PMC
Author	Cai, Zhaoyang Wang, Lu Han, Yali Gao, Wenwen Wei, Xiaojuan Gong, Rumei Zhu, Mingliang Sun, Yuping Yu, Shuwen
Copyright Year	2019
Abstract	Immunoglobulin like transcript (ILT) 4, a negative regulator of immune response in allograft rejection, autoimmunity and infectious diseases, has recently been determined to serve important roles in tumor development. In the present study, the co expression of ILT4 and human leukocyte antigen G (HLA-G) in tissues of human primary colorectal cancer (CRC) was revealed, and its association with older age, advanced stage, regional lymph node involvement and poor overall survival time was identified. In CRC cell lines, ILT4 and HLA-G co expression and their autocrine regulation was demonstrated. ILT4 interference affected HLA-G expression and regulated the cell proliferation, invasion and migration of CRC. HLA-G fusion protein treatment also increased ILT4 expression in a dose dependent manner, thereby activating protein kinase B (AKT) and extracellular signal regulated kinase (ERK) signaling, and facilitating the proliferation, migration and invasion of CRC cells. Additionally, the AKT and ERK activation, and CRC cell malignant characteristics induced by HLA-G may be suppressed by blocking ILT4. The present results indicated that the interaction of ILT4 and its ligand HLA-G promotes CRC progression through AKT and ERK signal activation, providing a novel strategy of blocking ILT4/HLA-G for the treatment of CRC.
ISSN	10196439
Journal	International Journal of Oncology
Volume Number	54
PubMed Central reference number	PMC6521940
Issue Number	6
PubMed reference number	30942436
e-ISSN	17912423
DOI	10.3892/ijo.2019.4761
Language	English
Publisher	D.A. Spandidos
Publisher Date	2019-03-22
Access Restriction	Open
Rights License	This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Copyright: © Cai et al.
Subject Keyword	CRC tumor progression ILT4 HLA-G prognostic biomarker
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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