Desperation surgery for a chemorefractory lung lesion in a patient with an extragonadal germ cell tumor.

Content Provider	Europe PMC
Author	Ishizuya, Yu Okusa, Takuya Hatano, Koji Nakai, Yasutomo Nakayama, Masashi Kakimoto, Ken-ichi Nishimura, Kazuo
Abstract	We report a case of recurrent and chemorefractory extragonadal germ cell tumor successfully treated with desperation surgery. A 25-year-old man presented with a mediastinal tumor with multiple lung metastases. Serum human chorionic gonadotropin (hCG) level was elevated. He was diagnosed with a mediastinal germ cell tumor (GCT) with multiple lung metastases. After second-line chemotherapy, serum hCG levels normalized. After a total of 10 cycles of chemotherapy, the mediastinal tumor was resected, with no viable tumor detected in the resected tissue. One month after the resection, serum hCG increased, accompanied by the appearance of a new lesion in the lung. After various regimens of salvage chemotherapies, serum hCG failed to normalize. Then, salvage surgery for the lung metastasis was performed. The resected tissue contained a viable choriocarcinoma. The patient remained free of disease without adjuvant therapy at 38 months after pneumonectomy.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6498312&blobtype=pdf
Volume Number	5
DOI	10.1007/s13691-016-0248-8
PubMed Central reference number	PMC6498312
Issue Number	3
PubMed reference number	31149445
Journal	International cancer conference journal [Int Cancer Conf J]
e-ISSN	21923183
Language	English
Publisher	Springer Japan
Publisher Date	2016-04-06
Publisher Place	Tokyo
Access Restriction	Open
Rights License	© The Japan Society of Clinical Oncology 2016
Subject Keyword	Extragonadal germ cell tumor Choriocarcinoma Lung metastases Desperation surgery Human chorionic gonadotropin
Content Type	Text
Resource Type	Article
Subject	Cancer Research