NDLI: Protein Kinase CK2, a Potential Therapeutic Target in Carcinoma Management

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Protein Kinase CK2, a Potential Therapeutic Target in Carcinoma Management

Content Provider	Europe PMC
Author	Lian, Haiwei Su, Min Zhu, Yijie Zhou, Yun Soomro, Shahid Hussain Fu, Hui
Copyright Year	2019
Abstract	The Protein kinase CK2 (formerly known as casein kinase 2) is a highly conserved serine/ threonine kinase overexpressed in various human carcinomas and its high expression often correlates with poor prognosis. CK2 protein is localized in the nucleus of many tumor cells and correlates with clinical features in many cases. Increased expression of CK2 in mice results in the development of various types of carcinomas (both solids and blood related tumors, such as (breast carcinoma, lymphoma, etc), which reveals its carcinogenic properties. CK2 plays essential roles in many key biological processes related to carcinoma, including cell apoptosis, DNA damage responses and cell cycle regulation. CK2 has become a potential anti-carcinoma target. Various CK2 inhibitors have been developed with anti-neoplastic properties against a variety of carcinomas. Some CK2 inhibitors have showed good results in in vitro and pre-clinical models, and have even entered in clinical trials. This article will review effects of CK2 and its inhibitors on common carcinomas in in vitro and pre-clinical studies.
ISSN	15137368
Volume Number	20
PubMed Central reference number	PMC6485562
Issue Number	1
PubMed reference number	30677865
Journal	Asian Pacific Journal of Cancer Prevention : APJCP [Asian Pac. J. Cancer Prev]
e-ISSN	2476762X
DOI	10.31557/APJCP.2019.20.1.23
Language	English
Publisher	West Asia Organization for Cancer Prevention
Publisher Date	2019-01-25
Publisher Place	Iran
Access Restriction	Open
Rights License	This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License Copyright: © Asian Pacific Journal of Cancer Prevention
Subject Keyword	Protein kinase CK2 solid tumors hematological tumors CX-4945 CIBG-300
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health Cancer Research Epidemiology Oncology

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