NDLI: Genetic differences between C57BL/6 substrains affect the process of testis differentiation in Y<sup>POS</sup> mice.

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Genetic differences between C57BL/6 substrains affect the process of testis differentiation in Y^POS mice.

Content Provider	Europe PMC
Author	YOKOYAMA, Toshifumi MIURA, Yuuka YAMAMOTO, Anzu HASEGAWA, Chinatsu KAWANISHI, Kohei TAKADA, Nanako OMOTEHARA, Takuya HIRANO, Tetsushi MANTANI, Yohei MIKI, Takanori HOSHI, Nobuhiko
Copyright Year	2019
Abstract	C57BL/6J-XYPOS (B6J-XYPOS) mice, which have the Y chromosomederived from Mus musculus poschiavinus on a B6J genetic background, formovotestes or ovaries. Previously, we replaced the genetic background ofB6J-XYPOS mice with B6N and found that individuals with testes also appearedin addition to those with ovaries or ovotestes. To investigate the effect of the B6Jgenetic sequence on the testis differentiation, the genetic background ofB6N-XYPOS mice was replaced with B6J again. The recovery of the B6J geneticbackground significantly decreased the incidence of testes; only ovaries developed. Theseresults indicate that the testicular differentiation process tends to be perturbedespecially in the B6J substrain. This shows the importance of substrain differences inmice usually treated as B6 collectively.
ISSN	09167250
Volume Number	81
PubMed Central reference number	PMC6483905
Issue Number	4
PubMed reference number	30828038
Journal	The Journal of Veterinary Medical Science [J. Vet. Med. Sci]
e-ISSN	13477439
DOI	10.1292/jvms.18-0621
Language	English
Publisher	The Japanese Society of Veterinary Science
Publisher Date	2019-03-04
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the CreativeCommons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0:https://creativecommons.org/licenses/by-nc-nd/4.0/) ©2019 The Japanese Society of Veterinary Science
Subject Keyword	C57BL/6 Mus musculus poschiavinus sex reversal substrain testis differentiation
Content Type	Text
Resource Type	Article
Subject	Veterinary

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Genetic differences between C57BL/6 substrains affect the process of testis differentiation in YPOS mice.

Genetic differences between C57BL/6 substrains affect the process of testis differentiation in Y^POS mice.