Endoscopic ultrasound-guided vs endoscopic retrograde cholangiopancreatography biliary drainage for obstructed distal malignant biliary strictures: A systematic review and meta-analysis.

Content Provider	Europe PMC
Author	Logiudice, Fernanda P Bernardo, Wanderlei M Galetti, Facundo Sagae, Vitor M Matsubayashi, Carolina O Madruga Neto, Antonio C Brunaldi, Vitor O de Moura, Diogo T H Franzini, Tomazo Cheng, Spencer Matuguma, Sergio E de Moura, Eduardo G H
Copyright Year	2019
Abstract	BACKGROUNDFor palliation of malignant biliary obstruction (MBO), the gold-standard method of biliary drainage is endoscopic retrograde cholangiopancreatography (ERCP) with the placement of metallic stents. Endoscopic ultrasound (EUS)-guided drainage is an alternative that is typically reserved for cases of ERCP failure. Recently, however, there have been robust randomized clinical trials (RCTs) comparing EUS-guided drainage and ERCP as primary approaches to MBO.AIMTo compare EUS guidance and ERCP in terms of their effectiveness and safety in palliative biliary drainage for MBO.METHODSThis was a systematic review and meta-analysis, in which we searched the MEDLINE, Excerpta Medica, and Cochrane Central Register of Controlled Trials databases. Only RCTs comparing EUS and ERCP for primary drainage of MBO were eligible. All of the studies selected provided data regarding the rates of technical and clinical success, as well as the duration of the procedure, adverse events, and stent patency. We assessed the risk of biases using the Jadad score and the quality of evidence using the Grading of Recommendations Assessment, Development and Evaluation criteria.RESULTSThe database searches yielded 5920 records, from which we selected 3 RCTs involving a total of 222 patients (112 submitted to EUS and 110 submitted to ERCP). In the EUS and ERCP groups, the rate of technical success was 91.96% and 91.81%, respectively, with a risk difference (RD) of 0.00% (95%CI: -0.07, 0.07; P = 0.97; I2 = 0%). The clinical success was 84.81% and 85.53% in the EUS and ERCP groups, respectively, with an RD of −0.01% (95%CI: -0.12, 0.10; P = 0.90; I2 = 0%). The mean difference (MD) for the duration of the procedure was -0.12% (95%CI: -8.20, 7.97; P = 0.98; I2 = 84%). In the EUS and ERCP groups, there were 14 and 25 adverse events, respectively, with an RD of -0.06% (95%CI: -0.23, 0.12; P = 0.54; I2 = 77%). The MD for stent patency was 9.32% (95%CI: -4.53, 23.18; P = 0.19; I2 = 44%). The stent dysfunction rate was significantly lower in the EUS group (MD = -0.22%; 95CI:-0.35, -0.08; P = 0.001; I2 = 0%).CONCLUSIONEUS represents an interesting alternative to ERCP for MBO drainage, demonstrating lower stent dysfunction rates compared with ERCP. Technical and clinical success, duration, adverse events and patency rates were similar.
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Journal	World Journal of Gastrointestinal Endoscopy [World J Gastrointest Endosc]
Volume Number	11
DOI	10.4253/wjge.v11.i4.281
PubMed Central reference number	PMC6475700
Issue Number	4
PubMed reference number	31040889
e-ISSN	19485190
Language	English
Publisher	Baishideng Publishing Group Inc
Publisher Date	2019-04-01
Access Restriction	Open
Rights License	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Subject Keyword	: Common bile duct neoplasms Endoscopic retrograde cholangiopancreatography Endosonography Ultrasonography Interventional/methods Endoscopic ultrasound Systematic review Meta-analysis
Content Type	Text
Resource Type	Article
Subject	Medicine