Lysozyme from hen egg white ameliorates lipopolysaccharide-induced systemic inflammation in mice.

Content Provider	Europe PMC
Author	Tagashira, Ayuka Nishi, Kosuke Sugahara, Takuya
Abstract	Lysozyme is an anti-bacterial protein that is widely distributed in nature. Our previous studies revealed that lysozyme shows anti-inflammatory effect on hyperinflammatory macrophages in vitro. The effect of lysozyme on lipopolysaccharide-induced inflammation model mice was examined in this study. Oral administration of lysozyme at 2250 mg/kg body weight/day (high-dose group) significantly suppressed interleukin (IL)-6 and tumor necrosis factor-α levels in the serum. IL-6 level in the spleen was significantly suppressed by lysozyme at 450 mg/kg body weight/day (middle-dose group) and high-dose group due to the suppression of gene expression level. The gene expression levels of IL-1β and IL-12 were also decreased by lysozyme in the high-dose group. In addition, lysozyme significantly suppressed IL-6 level in the liver in the high-dose group. Our findings suggest that lysozyme mitigates inflammatory condition in vivo by suppressing inflammatory cytokine levels in serum and organs from LPS-induced inflammation model mice.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6465377&blobtype=pdf
ISSN	09209069
Volume Number	71
DOI	10.1007/s10616-019-00296-4
PubMed Central reference number	PMC6465377
Issue Number	2
PubMed reference number	30721425
Journal	Cytotechnology
e-ISSN	15730778
Language	English
Publisher	Springer Netherlands
Publisher Date	2019-02-05
Publisher Place	Dordrecht
Access Restriction	Open
Rights License	© Springer Nature B.V. 2019
Subject Keyword	Anti-inflammation Lysozyme Lipopolysaccharide-induced systemic inflammation Inflammatory cytokine
Content Type	Text
Resource Type	Article
Subject	Cell Biology Clinical Biochemistry Bioengineering Biomedical Engineering Biotechnology