Screening and surveillance methods for dysplasia in inflammatory bowel disease patients: Where do we stand?

Content Provider	Europe PMC
Author	Galanopoulos, Michail Tsoukali, Emmanouela Gkeros, Filippos Vraka, Marina Karampekos, Georgios Matzaris, Gerassimos J
Copyright Year	2018
Abstract	Patients with long-standing ulcerative colitis (UC) and extensive Crohn’s colitis (CC) are at increased risk for dysplasia and colorectal cancer (CRC). Several studies have shown that UC extending proximal to the rectum, CC involving at least 1/3 of the colon, co-existence of primary sclerosing cholangitis, undetermined or unclassified colitis, family history of CRC and young age at diagnosis appear to be independent risk factors for inflammatory bowel disease (IBD) - related CRC. Therefore, screening and surveillance for CRC in IBD patients is highly recommended by international and national guidelines, whilst colonoscopy remains the unequivocal tool in order to detect potentially resectable dysplastic lesions or CRC at an early stage. Although the importance of screening and surveillance is widely proven, there is a controversy regarding the time of the first colonoscopy and the criteria of who should undergo surveillance. In addition, there are different recommendations among scientific societies concerning which endoscopic method is more efficient to detect dysplasia early, as well as the terminology for reporting visible lesions and the management of those lesions. This article concisely presents the main endoscopic methods and techniques performed for detecting dysplasia and CRC surveillance in patients with IBD focusing on their evidence-based accuracy and efficiency, as well as their cost-effectiveness. Finally, newer methods are mentioned, highlighting their applicability in daily endoscopic practice.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6198309&blobtype=pdf
Journal	World Journal of Gastrointestinal Endoscopy [World J Gastrointest Endosc]
Volume Number	10
DOI	10.4253/wjge.v10.i10.250
PubMed Central reference number	PMC6198309
Issue Number	10
PubMed reference number	30364842
e-ISSN	19485190
Language	English
Publisher	Baishideng Publishing Group Inc
Publisher Date	2018-10-01
Access Restriction	Open
Rights License	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Subject Keyword	Inflammatory bowel disease Ulcerative colitis Crohn’s disease Dysplasia Colorectal cancer Endoscopy Chromoendoscopy Surveillance
Content Type	Text
Resource Type	Article
Subject	Medicine