Monotonic Dose Effect of Bisphenol-A, an Estrogenic Endocrine Disruptor, on Estrogen Synthesis in Female Sprague-Dawley Rats.

Content Provider	Europe PMC
Author	Thilagavathi, Subbaiyan Pugalendhi, Pachaiappan Rajakumar, Thangarasu Vasudevan, Krishnamoorthy
Abstract	Bisphenol-A (BPA) is a ubiquitous environmental chemical that produces adverse effect on reproduction system due to its potent estrogenic endocrine disruptive activity. The present study was aimed to investigate the monotonic dose effect of BPA on estrogen synthesis in female Sprague-Dawley rats. For this purpose, we administered three different doses of BPA (10, 50, 100 µg/kg bw/day) into rats and analyzed various biochemical, hormonal, molecular and histological parameters. 10 µg BPA treated rats showed significantly decreased levels of phase I detoxification agents (CYP450, Cyt-b5). Overexpression of eNOS with decreased expression of StAR and steroidogenic enzymes (CYP11A1, aromatase) indicate decreased production of estrogen. Increased levels of serum gonadotropins (FSH, LH) and decreased levels of estradiol suggest mimetic action of BPA and its feedback inhibition. Increased body weight, lipid profile status of 10 µg BPA treated rats and histological analysis of ovary and mammary tissue support the study. Overall, our results suggest that BPA exerts its estrogen mimetic effects in a monotonic manner.
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ISSN	09701915
Volume Number	33
DOI	10.1007/s12291-017-0696-8
PubMed Central reference number	PMC6170246
Issue Number	4
PubMed reference number	30319184
Journal	Indian Journal of Clinical Biochemistry [Indian J Clin Biochem]
e-ISSN	09740422
Language	English
Publisher	Springer India
Publisher Date	2017-10-11
Publisher Place	New Delhi
Access Restriction	Open
Rights License	© Association of Clinical Biochemists of India 2017
Subject Keyword	Bisphenol-A Estrogen Ovary Mammary gland
Content Type	Text
Resource Type	Article
Subject	Clinical Biochemistry