NDLI: Klotho and Postmenopausal Hormone Replacement Therapy in Women with Chronic Kidney Disease.

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Klotho and Postmenopausal Hormone Replacement Therapy in Women with Chronic Kidney Disease.

Content Provider	Europe PMC
Author	Park, Yoo Jin Kim, Jun-Mo
Copyright Year	2018
Abstract	Kidney function is highly susceptible to age-related changes, with chronic kidney disease (CKD) serving as an important cause of morbidity and mortality in older patients. The prevalence of CKD in Korea is higher among the elderly, relative to the general population, with the most significant increases seen following the onset of menopause. Under normal conditions, estrogen attenuates renal superoxide production and protects the kidney from oxidative damage. As estrogen levels are known to decrease by as much as 80% during menopause, this represents a significant risk for older women. Postmenopausal hormone replacement therapy (HRT) modulates the renin-angiotensin system, thereby reducing the progressive deterioration of renal function. Use of estrogen-based HRT has been shown to ameliorate renal function in postmenopausal women, and delay CKD progression. Renal expression of klotho, an important suppressor of aging, is markedly decreased in CKD patients, making it a promising candidate for use as a prognostic biomarker in CKD. Here, we review the key links between renal function, sex, age, and estrogen levels during menopause, and discuss the use of postmenopausal HRT in CKD attenuation.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6127018&blobtype=pdf
ISSN	22886478
Journal	Journal of Menopausal Medicine [J Menopausal Med]
Volume Number	24
DOI	10.6118/jmm.2018.24.2.75
PubMed Central reference number	PMC6127018
Issue Number	2
PubMed reference number	30202755
e-ISSN	22886761
Language	English
Publisher	The Korean Society of Menopause
Publisher Date	2018-08-31
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/). Copyright © 2018 by The Korean Society of Menopause
Subject Keyword	Estrogen replacement therapy Hormone replacement therapy Postmenopause Renal insufficiency, chronic
Content Type	Text
Resource Type	Article
Subject	Obstetrics and Gynecology

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