Do Exposure to Arsenic, Occupation and Diet Have Synergistic Effects on Prostate Cancer Risk?

Content Provider	Europe PMC
Author	Román, María Dolores Niclis, Camila Aballay, Laura Rosana Lantieri, María Josefina Díaz, María Del Pilar Muñoz, Sonia Edith
Copyright Year	2018
Abstract	Background:Diverse environmental exposures, as well as dietary and lifestyle factors, are associated with prostate cancer (PC) etiology; however little is known about joint interactive influences. The aim of this study was to analyse effects of diet combined with arsenic in drinking water and agricultural occupation on PC risk.Methods:A case-control study was conducted in Córdoba, Argentina (period 2008-2015) including 147 cases of PC and 300 controls. All subjects were interviewed about food consumption, socio-demographic and lifestyle characteristics. A sample of drinking water was taken to determine arsenic concentrations. Adherence scores to the Traditional Dietary Pattern were estimated, based on a principal component factor analysis. A two-level logistic regression model was fitted in order to assess effects of the Traditional Pattern, occupation and arsenic exposure on the occurrence of PC (outcome). Family history of PC was considered as a clustering variable.Results:PC risk was greatest in subjects with high adherence to the Traditional Pattern (OR 2.18; 95%IC 1.097–4.344). Subjects exposed to arsenic in drinking water above 0.01mg/l who simultaneously performed agricultural activities showed a markedly elevated PC risk (OR 5.07; 95%IC 2.074-12.404). Variance of the random effect of family history of PC was significant.conclusion:Diet, arsenic and occupation in agriculture exert significant effects on PC risk. Further efforts are necessary to analyse risk factors integrally, in order to achieve a better understanding of the complex causal network for PC in this multiple-exposure population.
ISSN	15137368
Volume Number	19
PubMed Central reference number	PMC6103567
Issue Number	6
PubMed reference number	29936720
Journal	Asian Pacific Journal of Cancer Prevention : APJCP [Asian Pac. J. Cancer Prev]
e-ISSN	2476762X
DOI	10.22034/APJCP.2018.19.6.1495
Language	English
Publisher	West Asia Organization for Cancer Prevention
Publisher Date	2018-06-25
Publisher Place	Iran
Access Restriction	Open
Rights License	This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License Copyright: © Asian Pacific Journal of Cancer Prevention
Subject Keyword	Prostate cancer dietary patterns arsenic occupational exposure Córdoba-Argentina
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health Cancer Research Epidemiology Oncology