Loading...
Please wait, while we are loading the content...
Similar Documents
Uric acid promotes oxidative stress and enhances vascular endothelial cell apoptosis in rats with middle cerebral artery occlusion.
| Content Provider | Europe PMC |
|---|---|
| Author | Song, Chengfu Zhao, Xiangdong |
| Copyright Year | 2017 |
| Abstract | In patients with cerebral infarction (CI), elevated serum uric acid (UA) level may exacerbate the occurrence and development of carotid atherosclerosis (AS). Our study intended to explore the underlying mechanism. We enrolled 86 patients with CI, and divided them into four groups: Non-AS, AS-mild, AS-moderate, and AS-severe groups; the levels of UA and oxidative stress-related factors in serum were detected. The middle cerebral artery occlusion (MCAO) model was used to stimulate CI in rats, and different doses of UA were administrated. The levels of oxidative stress-related factors in serum were detected. Hematoxylin & eosin (H&E) staining was used to observe the morphological alterations, and the apoptotic cell death detection kit was used to detect apoptotic cells. Increased UA concentration and enhanced oxidative stress were found in AS patients. H&E staining results showed that UA treatment exacerbated morphological damage in rats with MCAO, promoted oxidative stress, and enhanced vascular endothelial cell apoptosis in rats with MCAO. |
| Page Count | 9 |
| ISSN | 01448463 |
| Volume Number | 38 |
| PubMed Central reference number | PMC6048215 |
| Issue Number | 3 |
| PubMed reference number | 29097484 |
| Journal | Bioscience Reports [Biosci. Rep] |
| e-ISSN | 15734935 |
| DOI | 10.1042/BSR20170939 |
| Language | English |
| Publisher | Portland Press Ltd. |
| Publisher Date | 2018-05-15 |
| Access Restriction | Open |
| Rights License | This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY). © 2017 The Author(s). |
| Subject Keyword | middle cerebral artery occlusion oxidative stress Uric acid vascular endothelial cell apoptosis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Biology Biochemistry Biophysics |
