Effects of Acute and Chronic Restraint Stress on Reinstatement of Extinguished Methamphetamine-induced Conditioned Place Preference in Rats.

Content Provider	Europe PMC
Author	Taslimi, Zahra Komaki, Alireza Haghparast, Abbas Sarihi, Abdolrahman
Copyright Year	2018
Abstract	Introduction:Methamphetamine (METH) is a neurotoxic psychostimulant with highly addictive potential that leads to compulsive drug use and vulnerability to relapse. Environmental cues, such as drug exposure, peer influence, and social stress, are the powerful triggers of drug relapse. In this study, we tried to find out the effect of acute and chronic restraint stress on reinstatement of extinguished METH-induced Conditioned Place Preference (CPP) in rats.Methods:Subcutaneous (SC) administration of METH (0.125, 0.25, 0.5, 1, 2 and 4 mg/kg) could induce CPP and it was found that METH with the dose of 0.5 mg/kg was more potent than other doses. In extinction phase, rats were put in the CPP box for 30 min per day for 8 consecutive days. After extinction, animals were exposed to restraint stress (3-h period, as an acute stress) 60 min before subcutaneous administration of ineffective dose of METH (0.125 mg/kg) in order to reinstate the extinguished METH-induced CPP. For induction of the chronic stress during extinction phase, the animals were exposed to the restraint stress for one hour per day.Results:The results showed that the effective dose of METH to induce CPP was 0.5 mg/kg. Based on the results, physical stress (restraint stress) whether acute and chronic, can significantly induce reinstatement of METH-induced CPP (P˂0.001) in extinguished animals.Conclusion:Additionally, the chronic restraint stress could reduce duration of extinction (maintenance) of METH-induced CPP. It seems that exposure to the stress induces the relapse in abstinent amphetamine, but acute and chronic situation have a different reaction.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6037431&blobtype=pdf
ISSN	2008126X
Journal	Basic and Clinical Neuroscience [Basic Clin Neurosci]
Volume Number	9
DOI	10.29252/nirp.bcn.9.3.157
PubMed Central reference number	PMC6037431
Issue Number	3
PubMed reference number	30034646
e-ISSN	22287442
Language	English
Publisher	Iranian Neuroscience Society
Publisher Date	2018-05-01
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright© 2018 Iranian Neuroscience Society
Subject Keyword	Reward Stress Methamphetamine (METH) Reinstatement Conditioned place preference
Content Type	Text
Resource Type	Article
Subject	Neurology (clinical) Cellular and Molecular Neuroscience