NDLI: New <sup>β</sup>N-octadecanoyl-5-hydroxytryptamide: antinociceptive effect and possible mechanism of action in mice.

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New ^βN-octadecanoyl-5-hydroxytryptamide: antinociceptive effect and possible mechanism of action in mice.

Content Provider	Europe PMC
Author	Giorno, Thais Biondino Sardella Moreira, Iris Gonçalvez da Silva Rezende, Claudia Moraes Fernandes, Patricia Dias
Abstract	The present study examined the potential antinociceptive activity of C18 5-HT (^βN-octadecanoyl-5-hydroxytryptamide) using chemical and thermal nociception models in mice. Orally administered C18 5-HT (0.1, 1 and 10 mg/kg) produced significant dose-dependent antinociceptive effects in formalin-, capsaicin- and glutamate-induced licking models. This compound also induced a significant increase in the response to thermal stimuli in the hot plate test, and its antinociceptive effect was not related to muscle relaxant or sedative actions. In a thermal hyperalgesia model, C18 5-HT presented an anti-hyperalgesic profile as evidenced by the increase in the response time of the animals. Furthermore, intraperitoneal (i.p) pretreatment with naloxone (a non-selective opioid receptor antagonist, 1 mg/kg), ondansetron (serotoninergic receptor antagonist (5-HT3 subtype), 0.5 mg/kg) or AM241 (CB1 cannabinoid receptor antagonist, 1 mg/kg) reversed the antinociceptive effects of C18 5-HT in the hot plate model. In the formalin-induced licking model, pretreatment with naloxone reversed the antinociceptive effects of C18 5-HT, as demonstrated by an increase in the paw licking response when compared with the C18 5-HT-treated group. These findings suggest that C18 5-HT has peripheral and central antinociceptive effects and that its mechanism of action involves, ate least in part, opioid, serotoninergic and cannabinoid pathways.
Journal	Scientific Reports [Sci Rep]
Volume Number	8
DOI	10.1038/s41598-018-28355-4
PubMed Central reference number	PMC6030208
Issue Number	1
PubMed reference number	29968799
e-ISSN	20452322
Language	English
Publisher	Nature Publishing Group
Publisher Date	2018-07-03
Publisher Place	London
Access Restriction	Open
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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