NDLI: Antidiabetic effects of novel cell culture established from grapevine, Vitis vinifera cv. Koshu.

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Antidiabetic effects of novel cell culture established from grapevine, Vitis vinifera cv. Koshu.

Content Provider	Europe PMC
Author	Fujita, Keiko Aoki, Yoshinao Suzuki, Shunji
Abstract	Vitis vinifera cv. Koshu is an indigenous cultivar in Japan and has several characteristics that distinguish it from European V. vinifera. In Japan, Koshu is the most popular cultivar for wine making. We report herein a cell culture established from Koshu for use as a system for the production of resveratrol and its derivatives. Grape cell culture YU-1 was developed from the apex tissues of Koshu. YU-1 growth was favorably compared with BY-2 growth, a standard cell line in plant cell biology. Stilbene production and stilbene synthesis gene expression in YU-1 were upregulated by UV-C irradiation. YU-1 irradiated with UV-C decreased hemolymph sugar levels in model animals. Taken together, this study suggests that YU-1 may be used as a source of valuable medicinal components in plant cell bioreactor systems.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6021287&blobtype=pdf
ISSN	09209069
Volume Number	70
DOI	10.1007/s10616-018-0203-y
PubMed Central reference number	PMC6021287
Issue Number	3
PubMed reference number	29546683
Journal	Cytotechnology
e-ISSN	15730778
Language	English
Publisher	Springer Netherlands
Publisher Date	2018-03-15
Publisher Place	Dordrecht
Access Restriction	Open
Rights License	© Springer Science+Business Media B.V., part of Springer Nature 2018
Subject Keyword	Antidiabetic Hypoglycemic effect Koshu Resveratrol Vitis vinifera
Content Type	Text
Resource Type	Article
Subject	Cell Biology Clinical Biochemistry Bioengineering Biomedical Engineering Biotechnology

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