Immunoexpression of cyclin D1 in colorectal carcinomas is not correlated with survival outcome.

Content Provider	Europe PMC
Author	Al-Maghrabi, Jaudah Mufti, Shagufta Gomaa, Wafaey Buhmeida, Abdelbaset Al-Qahtani, Mohammed Al-Ahwal, Mahmoud
Copyright Year	2015
Abstract	Background:Colon and colorectal cancer (CRC) research has entered a new era with recent updates of molecular events and prognostic markers. Among other prognostic markers, exaggerated expression of nuclear CCND1 has key role in tumour pathogenesis and metastases of CRC and has also been claimed to predict response to treatment.Objectives:This study was designed to evaluate the prognostic and predictive value of CCND1 in CRC and the correlation of CCND1 expression with the different clinicopathological parameters.Methods:Paraffin blocks from 117 primary CRC were retrieved from the archives of the Department of Pathology at King Abdulaziz University. Tissue microarrays were designed and constructed. The immunostaining of CCND1 was performed and analysed.Results:There were more cases with low nuclear immunoexpression of CCND1 in both primary tumours and nodal metastasis (p <0.001). Cyclin D1 did not show association with clinicopathological features except with lymphovascular invasion. Low nuclear immunoexpression of CCND1 was associated with negative lymphovascular invasion (p = 0.046). There was no statistically significant correlation between CCND1 immunoexpression and survival probability (Log Rank = 2.474, p = 0.116).Conclusion:Our study indicates that CCND1 immunoexpression cannot be used as a predictor of survival in CRC. It also shows no significant correlation with clinicopathological features except with lymphovascular invasion.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6014192&blobtype=pdf
ISSN	2213879X
Journal	Journal of Microscopy and Ultrastructure [J Microsc Ultrastruct]
Volume Number	3
DOI	10.1016/j.jmau.2015.01.001
PubMed Central reference number	PMC6014192
Issue Number	2
PubMed reference number	30023183
e-ISSN	22138803
Language	English
Publisher	Medknow Publications & Media Pvt Ltd
Publisher Date	2015-02-03
Publisher Place	India
Access Restriction	Open
Rights License	This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Copyright: © 2015 Saudi Society of Microscopes
Subject Keyword	Colorectal cancer Immunohistochemistry Cyclin D1 Prognosis Survival
Content Type	Text
Resource Type	Article
Subject	Instrumentation Electronic, Optical and Magnetic Materials Pathology and Forensic Medicine Nephrology