Inter-Vendor and Inter-Session Reliability of Diffusion Tensor Imaging: Implications for Multicenter Clinical Imaging Studies.

Content Provider	Europe PMC
Author	Min, Jeeyoung Park, Mina Choi, Jin Woo Jahng, Geon-Ho Moon, Won-Jin
Copyright Year	2018
Abstract	ObjectiveTo evaluate the inter-vendor and inter-session reliability of diffusion tensor imaging (DTI) and relevant parameters.Materials and MethodsThis prospective study included 10 healthy subjects (5 women and 5 men; age range, 25–33 years). Each subject was scanned twice using 3T magnetic resonance scanners from three different vendors at two different sites. A voxel-wise statistical analysis of diffusion data was performed using Tract-Based Spatial Statistics. Fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD) values were calculated for each brain voxel using FMRIB's Diffusion Toolbox.ResultsA repeated measures analysis of variance revealed that there were no significant differences in FA values across the vendors or between sessions; however, there were significant differences in MD values between the vendors (p = 0.020). Although there were no significant differences in inter-session MD and inter-session/inter-vendor RD values, a significant group × factor interaction revealed differences in MD and RD values between the 1st and 2nd sessions conducted by the vendors (p = 0.004 and 0.006, respectively).ConclusionAlthough FA values exhibited good inter-vendor and inter-session reliability, MD and RD values did not show consistent results. Researchers using DTI should be aware of these limitations, especially when implementing DTI in multicenter studies.
ISSN	12296929
Journal	Korean Journal of Radiology
Volume Number	19
PubMed Central reference number	PMC6005957
Issue Number	4
PubMed reference number	29962884
e-ISSN	20058330
DOI	10.3348/kjr.2018.19.4.777
Language	English
Publisher	The Korean Society of Radiology
Publisher Date	2018-06-14
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2018 The Korean Society of Radiology
Subject Keyword	Brain Diffusion tensor imaging Magnetic resonance Reliability Reproducibility
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging