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Macular Choroidal Thickening in Keratoconus Patients: Swept-Source Optical Coherence Tomography Study.
| Content Provider | Europe PMC |
|---|---|
| Author | Gutierrez-Bonet, Rosa Ruiz-Medrano, Jorge Peña-Garcia, Pablo Catanese, Muriel Sadeghi, Yalda Hashemi, Katayoon Gabison, Eric Ruiz-Moreno, José M. |
| Copyright Year | 2018 |
| Abstract | PurposeTo determine the choroidal thickness (CT) profile in keratoconus (KC) patients using swept-source optical coherence tomography (SS-OCT).MethodsThis was a prospective, cross-sectional study. One hundred two eyes of 52 KC patients were studied using Pentacam and SS-OCT. The macular CT profile was created by manually measuring the distance between the retinal pigment epithelium and the choroid-sclera junction on horizontal b-scans at nine different macular locations. The results were compared to 93 eyes of 93 healthy controls.ResultsMean age of the KC group was 34.9 ± 13.5 years and mean axial length (AL) was 24.1 ± 1.3 mm. Mean topographic KC classification (TKC) was 2.0; 39 eyes were classified as early KC (TKC <1–2), 34 eyes as moderate (TKC 2, 2–3), and 29 as advanced (TKC 3+). Mean subfoveal CT was 383.2 μm in KC patients and 280.5 μm in control group (P < 0.001). CT in KC patients was statistically thicker in all measure locations (P < 0.001). CT in KC eyes decreased with age, approaching control group at >45 years old, losing statistical significance (P = 0.37).ConclusionsCT in KC patients is statistically thicker than in healthy population. After age 45, CT decreases approaching control group values.Translational RelevanceThis study describes changes in the CT profile of KC patients, a disease that was considered purely corneal. These choroidal changes argue that KC is a disease that likely involves several ocular structures other than the cornea, and could open new research lines related to the pathophysiology of KC. |
| Journal | Translational Vision Science & Technology |
| Volume Number | 7 |
| PubMed Central reference number | PMC5991807 |
| Issue Number | 3 |
| PubMed reference number | 29888113 |
| e-ISSN | 21642591 |
| DOI | 10.1167/tvst.7.3.15 |
| Language | English |
| Publisher | The Association for Research in Vision and Ophthalmology |
| Publisher Date | 2018-05-01 |
| Access Restriction | Open |
| Rights License | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. Copyright 2018 The Authors |
| Subject Keyword | keratoconus choroid swept-source OCT choroidal thickness SS-OCT |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomedical Engineering Ophthalmology |
