NDLI: Human amnion-derived mesenchymal stem cells induced osteogenesis and angiogenesis in human adipose-derived stem cells via ERK1/2 MAPK signaling pathway.

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Human amnion-derived mesenchymal stem cells induced osteogenesis and angiogenesis in human adipose-derived stem cells via ERK1/2 MAPK signaling pathway.

Content Provider	Europe PMC
Author	Wang, Yuli Chen, Xichen Yin, Ying Li, Song
Copyright Year	2018
Abstract	Mesenchymal stem cells (MSCs) have shown great potential in treating bone deficiency. Human adipose-derived stem cells (HASCs) are multipotent progenitor cells with multi-lineage differentiation potential. Human amnion-derived mesenchymal stem cells (HAMSCs) are capable of promoting osteogenic differentiation of MSCs. In this study, we investigated the effect of HAMSCs on HASCs by a transwell co-culture system. HAMSCs promoted proliferation, osteogenic differentiation, angiogenic potential and adiponectin (APN) secretion of HASCs. Moreover, the positive effect of HAMSCs was significantly inhibited by U0126, a highly selective inhibitor of extracellular signaling-regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinase (MAPK) signaling pathway. These observations suggested that HAMSCs induced bone regeneration in HASCs via ERK1/2 MAPK signaling pathway.
ISSN	19766696
Journal	BMB Reports
Volume Number	51
PubMed Central reference number	PMC5933215
Issue Number	4
PubMed reference number	29429450
e-ISSN	1976670X
DOI	10.5483/BMBRep.2018.51.4.005
Language	English
Publisher	Korean Society for Biochemistry and Molecular Biology
Publisher Date	2018-04-01
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2018 by the The Korean Society for Biochemistry and Molecular Biology
Subject Keyword	Angiogenesis ERK1/2 MAPK signaling pathway Human adipose-derived stem cells Human amnion-derived mesenchymal stem cells Osteogenesis
Content Type	Text
Resource Type	Article
Subject	Medicine Molecular Biology Biochemistry

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