Evaluation of Alterations in Tumor Tissue of Gastrointestinal Stromal Tumor (GIST) in Computed Tomography Following Treatment with Imatinib.

Content Provider	Europe PMC
Author	Werewka-Maczuga, Agnieszka Stępień, Monika Urbanik, Andrzej
Copyright Year	2017
Abstract	SummaryBackgroundThe aim of this study was to evaluate the alterations in the neoplastic tissue of GIST following Imatinib treatment.Material/MethodsCT studies of 14 patients with inoperable primary tumors and 56 patients with metastatic and recurrent disease after chemotherapy were analyzed retrospectively. The following alterations in features of primary and secondary tumors were analyzed: dimension, degree and type of contrast enhancement, outlines of lesions, presence of intratumoral bleeding, presence of calcifications.ResultsIn the analyzed group of primary, metastatic and recurrent tumors after treatment with Imatinib in most cases a decrease in size and contrast enhancement were observed; the outlines of lesions became well circumscribed. Following the treatment, the number of tumors enhancing inhomogeneously decreased. In primary tumors the percentage of calcifications increased, whereas in metastatic tumors calcifications were observed only after treatment. There was no bleeding found within primary tumors after treatment. In metastatic disease, increased percentage of tumors with transient intratumoral bleeding was observed. There were also some unconventional CT images following treatment, such as: cystic transformation of lesions, enlargement of lesions, appearing of new lesions suggesting progression of the disease, stationary dimensions of lesions during local progression of the disease, simultaneous decrease and increase in size of metastatic lesions or appearance of new ones.ConclusionsRight from the start of Imatinib therapy in inoperable and disseminated GIST patients, specific CT images, not seen during conventional cytotoxic chemotherapy, were observed.
ISSN	1733134X
Journal	Polish Journal of Radiology
Volume Number	82
PubMed Central reference number	PMC5894004
PubMed reference number	29657650
e-ISSN	18990967
DOI	10.12659/PJR.902944
Language	English
Publisher	Termedia Publishing House
Publisher Date	2017-12-15
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0). License allowing third parties to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially. Copyright © Polish Medical Society of Radiology 2017
Subject Keyword	Drug Therapy Gastrointestinal Stromal Tumors Multidetector Computed Tomography
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging