Extended-Duration Treatment of Superficial Vein Thrombosis of the Lower Limbs with Tinzaparin.

Content Provider	Europe PMC
Author	Nikolakopoulos, Konstantinos M. Kakkos, Stavros K. Papageorgopoulou, Chrysanthi P. Tsolakis, Ioannis A.
Copyright Year	2018
Abstract	PurposeTo identify risk factors for recurrent thromboembolic events (RTEs) and define the optimum duration of treatment with tinzaparin in patients with superficial vein thrombosis (SVT) of the lower limbs.Materials and MethodsA total of 147 consecutive patients with significant SVT were treated with subcutaneously administered tinzaparin. The composite primary endpoint of the study was RTE, deep-vein thrombosis (DVT) and/or pulmonary embolism (PE) at 120 days. Patients were stratified into group A, where patients received a variable dose of tinzaparin for up to 60 days (n=98), and a subsequent group B-ext, where patients received a standardized intermediate dose of tinzaparin (n=49) for 90 days.ResultsRTEs occurred in 15/147 patients (10.2%), including recurrent SVT (n=10), DVT (n=4) and fatal PE (n=1). RTEs were less frequent in group B-ext (0% vs. 15.3% for group A, P=0.004), a difference that remained significant at the one-year follow-up. Clinically extensive SVT was an independent predictor for RTEs (hazard ratio, 5.94; 95% confidence interval, 2.05–17.23; P=0.001, Cox regression). Predictors or DVT or PE in group A included clinically extensive SVT (P=0.004), absence of local pain (P=0.023) and the ultrasound findings of superficial axial vein thrombosis (any, P=0.006 or isolated, P=0.036) and multiple thrombosed superficial venous sites (P<0.001).ConclusionAn extended three-month regimen of tinzaparin in patients with SVT of the lower limbs is more effective than a shorter course and may be desirable in patients with risk factors.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5880338&blobtype=pdf
ISSN	22887970
Journal	Vascular Specialist International [Vasc Specialist Int]
Volume Number	34
DOI	10.5758/vsi.2018.34.1.1
PubMed Central reference number	PMC5880338
Issue Number	1
PubMed reference number	29629359
e-ISSN	22887989
Language	English
Publisher	Vascular Specialist International
Publisher Date	2018-03-31
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2018, The Korean Society for Vascular Surgery
Subject Keyword	Thrombophlebitis Heparin Recurrence Venous thrombosis
Content Type	Text
Resource Type	Article
Subject	Surgery Cardiology and Cardiovascular Medicine