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Oxidative Stress and Cardiac Remodeling: An Updated Edge.
| Content Provider | Europe PMC |
|---|---|
| Author | Rababa’h, Abeer M. Guillory, Ashley N. Mustafa, Rima Hijjawi, Tamara |
| Copyright Year | 2018 |
| Abstract | Background: A common phenotype associated with heart failure is the development of cardiac hypertrophy. Cardiac hypertrophy occurs in response to stress, such as hypertension, coro-nary vascular disease, or myocardial infarction. The most critical pathophysiological conditions in-volved may include dilated hypertrophy, fibrosis and contractile malfunction. The intricate pathophys-iological mechanisms of cardiac hypertrophy have been the core of several scientific studies, which may help in opening a new avenue in preventive and curative procedures.Objectives: To our knowledge from the literature, the development of cardiac remodeling and hyper-trophy is multifactorial. Thus, in this review, we will focus and summarize the potential role of oxida-tive stress in cardiac hypertrophy development.Conclusion: Oxidative stress is considered a major stimulant for the signal transduction in cardiac cells pathological conditions, including inflammatory cytokines, and MAP kinase. The understanding of the pathophysiological mechanisms which are involved in cardiac hypertrophy and remodeling process is crucial for the development of new therapeutic plans, especially that the mortality rates re-lated to cardiac remodeling/dysfunction remain high |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5872263&blobtype=pdf |
| ISSN | 1573403X |
| Journal | Current Cardiology Reviews [Curr Cardiol Rev] |
| Volume Number | 14 |
| PubMed Central reference number | PMC5872263 |
| Issue Number | 1 |
| PubMed reference number | 29332590 |
| e-ISSN | 18756557 |
| DOI | 10.2174/1573403x14666180111145207 |
| Language | English |
| Publisher | Bentham Science Publishers |
| Publisher Date | 2018-03-01 |
| Access Restriction | Open |
| Rights License | This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. © 2018 Bentham Science Publishers |
| Subject Keyword | Reactive oxygen species mitochondria remodeling protein kinase-C NAPDH hypertrophy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cardiology and Cardiovascular Medicine |
