Importance of Number of Foci of Capsular Invasion in Follicular Thyroid Carcinoma.

Content Provider	Europe PMC
Author	Kumar, Chitresh Mishra, Anjali Kumari, Niraj Krishnani, Narendra Chand, Gyan Agarwal, Gaurav Agarwal, Amit Mishra, Saroj Kanta
Abstract	The importance of capsular invasion in follicular thyroid carcinoma (FTC) has not been extensively studied. The aim of the present study was to correlate the clinical features and outcome of FTC with histology features particularly emphasizing on the importance of the number of foci of capsular invasion. This was a retrospective study. Histology of 123 FTC patients was reviewed. Patients were divided in three groups based on the number of foci of vascular and capsular invasion noted in primary tumor: group 1—capsular invasion at <6 and vascular invasion at <4 foci, group 2—either capsular invasion ≥6 or vascular invasion at ≥4 foci, and group 3—capsular invasion ≥6 and vascular invasion at ≥4 foci. Different prognostic factors and overall survival (OS) were compared among the groups. The incidences of distant metastases (p = 0.008) and OS (p = <0.001) were significantly different among the groups. On univariate analysis, age (p = 0.001), tumor size (p = <0.0001), distant metastases (p = <0.0001), vascular invasion (p = 0.018), and capsular invasion (p = 0.003) were significantly associated with OS. On multivariate analysis, age (p = 0.020), distant metastases (p = 0.045), and foci of capsular invasion (p = 0.005) were significant. The number of foci of capsular invasion seems to have significant prognostic value in widely invasive FTC.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5856682&blobtype=pdf
ISSN	09757651
Volume Number	9
DOI	10.1007/s13193-016-0610-5
PubMed Central reference number	PMC5856682
Issue Number	1
PubMed reference number	29563727
Journal	Indian Journal of Surgical Oncology [Indian J Surg Oncol]
e-ISSN	09766952
Language	English
Publisher	Springer India
Publisher Date	2016-12-24
Publisher Place	New Delhi
Access Restriction	Open
Rights License	© Indian Association of Surgical Oncology 2016
Subject Keyword	Widely invasive FTC Minimally invasive FTC Angioinvasive FTC Developing country
Content Type	Text
Resource Type	Article
Subject	Surgery Oncology