NDLI: The prognostic value of p62 in solid tumor patients: a meta-analysis.

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The prognostic value of p62 in solid tumor patients: a meta-analysis.

Content Provider	Europe PMC
Author	Ruan, Haihua Xu, Jingyue Wang, Lingling Zhao, Zhenyu Kong, Lingqin Lan, Bei Li, Xichuan
Copyright Year	2018
Abstract	p62, as a scaffolding/adaptor protein, is involved in multiple physiological processes include inflammation, autophagy and mitosis. However, the influence of p62 in cancer patients has not been comprehensively investigated. Moreover, the prognostic value of p62 for the survival of patients with solid tumors remains controversial. In this present meta-analysis, twenty suitable articles were identified from PubMed, EMBASE and Web of Science, Nature databases, including 4271 patients. A random-effect or fixed-effect model was adopted to correlate p62 expression with different outcome measured in entire tumors. Combined with results of hazard ratios (HRs) and 95% confidence intervals (CIs), we concluded that higher expression of p62 is associated with poorer overall survival (OS) (HR: 2.22, 95% CI: 1.82–2.71, P < 0.05), disease-free survival (DFS) (HR = 2.48, 95% CI: 1.78–3.46, P < 0.05) and even certain clinicopathological parameters, such as lymph node metastasis (RR = 1.21, 95% CI: 1.06–1.37) and clinical stages (RR = 1.27, 95% CI: 1.12–1.45), in cancer patients. Consequently, our data showed that p62 might be an effective poor prognostic factor for patients with various solid tumors.
Journal	Oncotarget
Volume Number	9
PubMed Central reference number	PMC5790537
Issue Number	3
PubMed reference number	29423120
e-ISSN	19492553
DOI	10.18632/oncotarget.23101
Language	English
Publisher	Impact Journals LLC
Publisher Date	2017-12-07
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright: © 2018 Ruan et al.
Subject Keyword	solid tumors p62 prognosis meta-analysis
Content Type	Text
Resource Type	Article
Subject	Oncology

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