Cognition, serum BDNF levels, and BDNF Val66Met polymorphism in type 2 diabetes patients and healthy controls.

Content Provider	Europe PMC
Author	Zhen, Yan-Feng Liu, Xing-Yu Zhou, Dong-Hao Du, Xiangdong Yin, Guangzhong Zhang, Yingyang Fang, Hui Xu, Gang Soares, Jair C. Zhang, Xiang Yang
Copyright Year	2018
Abstract	Background and aimsType 2 diabetes (T2DM) is associated with cognitive deficits. However, their pathophysiological mechanisms are still unknown. Recent study suggests that brain-derived neurotrophic factor (BDNF) is correlated with cognitive deficits in T2DM patients. This study was to determine whether altered serum BDNF levels and cognitive deficits depended on the BDNF Val66Met polymorphism in T2DM.ResultsThe BDNF Val66Met polymorphism may not contribute directly to the susceptibility to T2DM. The total and nearly all index scores (all p < 0.01) except for the attention and visuospatial/constructional indexes (both p > 0.05) of RBANS were markedly decreased in T2DM compared with healthy controls. Serum BDNF levels were significantly lower in patients than that in controls (p < 0.001), and BDNF was positively associated with delayed memory in patients (p < 0.05). The Met variant was associated with worse delayed memory performance among T2DM patients but not among normal controls. Moreover, serum BDNF was positively associated with delayed memory among Met homozygote patients (β = 0.29, t = 2.21, p = 0.033), while serum BDNF was negatively associated the RBANS total score (β = –0.92, t = –3.40, p = 0.002) and language index (β = −1.17, t = –3.54, p = 0.001) among Val homozygote T2DM patients.ConclusionsBDNF gene Val66Met variation may be associated with cognitive deficits in T2DM, especially with delayed memory. The association between lower BDNF serum levels and cognitive impairment in T2DM is dependent on the BDNF Val66Met polymorphism.MethodsWe recruited 311 T2DM patients and 346 healthy controls and compared them on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), serum BDNF levels, and the BDNF Val66Met polymorphism.
Journal	Oncotarget
Volume Number	9
PubMed Central reference number	PMC5790490
Issue Number	3
PubMed reference number	29423073
e-ISSN	19492553
DOI	10.18632/oncotarget.23342
Language	English
Publisher	Impact Journals LLC
Publisher Date	2017-12-16
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright: © 2018 Zhen et al.
Subject Keyword	type 2 diabetes brain-derived neurotrophic factor cognition polymorphism association
Content Type	Text
Resource Type	Article
Subject	Oncology