Second Primary Cancer Risk among Kidney Cancer Patients in Korea: A Population-Based Cohort Study.

Content Provider	Europe PMC
Author	Joung, Jae Young Kwon, Whi-An Lim, Jiwon Oh, Chang-Mo Jung, Kyu-Won Kim, Sung Han Seo, Ho Kyung Park, Weon Seo Chung, Jinsoo Lee, Kang Hyun Won, Young-Joo
Copyright Year	2018
Abstract	PurposeSecondary primary cancers (SPCs) commonly arise in patients with renal cell carcinoma (RCC). We designed the present study to estimate the SPC incidence in Korean patients with RCC.Materials and MethodsThe study cohort was population-based and consisted of 40,347 individuals from the Korean Central Cancer Registry who were diagnosed with primary renal cancer between 1993 and 2013. Standardized incidence ratios (SIRs) for SPCs were estimated for different ages at diagnosis, latencies, diagnostic periods, and treatments.ResultsFor patients with primary RCC, the risk of developing a SPC was higher than the risk of developing cancer in the general population (SIR, 1.13; 95% confidence interval, 1.08 to 1.18). Most cancer types showed higher incidences in patients with RCC than in the general population. However, the relative incidence of gastric cancer as an SPC varied by age. Gastric cancer incidence was elevated in young patients (< 30 years) with RCC, but reduced in older (≥ 30) patients with RCC. Patients with advanced RCC died prematurely, regardless of SPC development. In contrast, those with early-stage RCC survived for longer periods, although SPC development affected their post-RCC survival. After SPC development, women had better survival than men.ConclusionIn Korean patients with primary RCC, the incidence of SPC was 13% higher than the incidence of cancer in the general population. These findings may play important roles in the conduct of follow-up evaluations and education for patients with RCC.
ISSN	15982998
Journal	Cancer Research and Treatment : Official Journal of Korean Cancer Association
Volume Number	50
PubMed Central reference number	PMC5784635
Issue Number	1
PubMed reference number	28421722
e-ISSN	20059256
DOI	10.4143/crt.2016.543
Language	English
Publisher	Korean Cancer Association
Publisher Date	2017-04-19
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2018 by the Korean Cancer Association
Subject Keyword	Renal cell carcinoma Second primary neoplasms Prognosis Incidence Survival
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology