NDLI: Elasto-inertial migration of deformable capsules in a microchannel.

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Elasto-inertial migration of deformable capsules in a microchannel.

Content Provider	Europe PMC
Author	Raffiee, Amir Hossein Dabiri, Sadegh Ardekani, Arezoo M.
Copyright Year	2017
Abstract	In this paper, we study the dynamics of deformable cells in a channel flow of Newtonian and polymeric fluids and unravel the effects of deformability, elasticity, inertia, and size on the cell motion. We investigate the role of polymeric fluids on the cell migration behavior and the performance of inertial microfluidic devices. Our results show that the equilibrium position of the cell is on the channel diagonal, in contrast to that of rigid particles, which is on the center of the channel faces for the same range of Reynolds number. A constant-viscosity polymeric fluid, modeled using an Oldroyd-B constitutive equation, drives the cells toward the channel centerline, while a shear-thinning polymeric fluid, modeled using a Giesekus constitutive equation, pushes the cells toward the channel wall. The findings of this paper suggest that the addition of polymers in microfluidic devices can be used to enhance the throughput of cell focusing and separation devices at a low cost. This study provides an insight on the role of rheological properties of the fluid and the ways that they can be tuned to control the focal position of the cells.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5745194&blobtype=pdf
Page Count	16
Volume Number	11
DOI	10.1063/1.5004572
PubMed Central reference number	PMC5745194
Issue Number	6
PubMed reference number	29333202
Journal	Biomicrofluidics
e-ISSN	19321058
Language	English
Publisher	AIP Publishing LLC
Publisher Date	2017-11-01
Access Restriction	Open
Rights License	Published by AIP Publishing. Copyright © 2017 Author(s)
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Condensed Matter Physics Molecular Biology Colloid and Surface Chemistry Fluid Flow and Transfer Processes Nanoscience and Nanotechnology Biomedical Engineering Genetics Materials Science

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